Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Fluorouracil

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2222-2

Synonyms

Definition

Is a drug primarily used in cancer treatment. It is considered a pyrimidine analog belonging to the class of drugs known as antimetabolites. This chemotherapy agent has been used against cancer for about 40 years and appears to have multiple sites of action. As a pyrimidine analog it is activated inside the cell to a cytotoxic metabolite that is incorporated into RNA and DNA. This action causes cell cycle arrest and, in many instances, induces apoptosis. Because its main actions involve DNA synthesis, this agent is considered an S-phase-specific drug and is active during this phase of the cell cycle in actively dividing cells.

Characteristics

Fluorouracil continues to have wide use in the treatment of cancer. Research over the past several years has increased our understanding of how 5-FU inhibits cell growth, and this has led to the development of new strategies that have increased the utility of this anticancer drug. However, drug resistance...

Keywords

Thymidine Phosphorylase Pyrimidine Analog Cytosine Deamination Elevated Pool Fluoropyrimidine Carbamate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  5. Noordhuis P, Holwerda U, Van der Wilt CL et al (2004) 5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers. Ann Oncol 157:1025–1032CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Molecular BiologyRowan University School of Osteopathic MedicineStratfordUSA