Extracellular Signal-Regulated Kinases 1 and 2
The extracellular signal-regulated kinases (ERKs) 1 and 2 (also referred to as mitogen-activated protein kinases 1 and 2; MAPK1/2) constitute major regulators of cell proliferation and survival and also regulate motility, differentiation, and senescence. They phosphorylate a multitude of cytoplasmic and nuclear substrates, including transcription factors. Mutations or overexpression of upstream ERK activators are implicated in oncogene-induced signaling in a wide variety of tumors. Inhibitors of ERK activation are used in cancer therapy.
The ERK Activation Cascade
KeywordsHuman Epidermal Growth Factor Receptor Papillary Thyroid Carcinoma Focal Adhesion Kinase BRAF Mutation Serum Response Factor
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