Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Erythropoietin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2002-2

Synonyms

Definition

Erythropoietin (Epo) (from Greek erythro for red and poietin to make) is a small glycoprotein hormone that is essential for the production of red blood cells. Epo promotes the survival, proliferation, and differentiation of erythroid progenitor cells (BFU-E, CFU-E) to mature erythrocytes and initiates hemoglobin synthesis.

Characteristics

The Epo gene contains at least five exons and resides on chromosome 7q21-q22 in humans and chromosome 5 in mice. DNA sequences from monkey and mouse display 90 % and 80 % homology to human Epo, respectively. Epo is produced primarily in the kidney and to a lesser extent in the liver. It is an acidic glycoprotein hormone with a molecular weight of 34–37 kD and circulates in the blood plasma at a very low concentration (about 5 pmol/l). It is composed of a single chain polypeptide and is resistant to denaturation by heat, alkali, or...

Keywords

Polycystic Kidney Disease Polycythemia Vera Erythroid Progenitor Erythroid Progenitor Cell Normocytic Anemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Hardee ME, Acrasoy MO, Blackwell KL et al (2006) Erythropoietin biology in cancer. Clin Cancer Res 12:332–339CrossRefPubMedGoogle Scholar
  2. Heuser M, Ganser A (2006) Recombinant human erythropoietin in the treatment of nonrenal anemia. Ann Hematol 85:69–78CrossRefPubMedGoogle Scholar
  3. Jelkman W (1992) Erythropoietin, structure, control of production and function. Physiol Rev 72:449–489Google Scholar
  4. Lipton S (2004) Erythropoietin for neurological protection and diabetic neuropathy. N Eng J Med 350:2516–2517CrossRefGoogle Scholar
  5. Wojchowski DM, Gregory RC, Miller CP et al (1999) Signal transduction in the erythropoietin receptor system. Exp Cell Res 253:143–156CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Jilin UniversityChangchunChina
  2. 2.Division of Molecular and Cellular BiologySunnybrook Health Sciences CentreTorontoCanada