Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

ABVD

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_18-2

Definition

Doxorubicin, bleomycin, vinblastine, and dacarbazine combination chemotherapy used for the treatment of patients with Hodgkin lymphoma.

Characteristics

ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) is the most widely used regimen for the treatment of early and advanced stage Hodgkin lymphoma (HL). Treatment of patients with early stage classical HL evolved over the last three decades. Radiation therapy alone as the single treatment modality is no longer practiced. Today, the most widely used approach is combined modality therapy (chemotherapy plus involved field radiation therapy). In general, two (for favorable early stage) to four (for unfavorable early stage) cycles of ABVD plus 20 to 30 Gy of involved field radiation therapy is the most widely used standard of care approach. Using this approach, more than 90 % of the patients are expected to be cured of their disease. More recently, functional imaging is used to guide therapy aiming at eliminating the need...

Keywords

Hodgkin Lymphoma Autologous Stem Cell Transplantation Combine Modality Poor Risk Combine Modality Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bonadonna G, Bonfante V, Viviani S et al (2004) ABVD plus subtotal nodal versus involved-field radiotherapy in early-stage Hodgkin’s disease: long-term results. J Clin Oncol 22:2835–2841CrossRefPubMedGoogle Scholar
  2. Canellos GP (1996) Is ABVD the standard regimen for Hodgkin’s disease based on randomized CALGB comparison of MOPP, ABVD and MOPP alternating with ABVD? Leukemia 10(Suppl 2):s68PubMedGoogle Scholar
  3. Diehl V, Thomas RK, Re D (2004) Part II: Hodgkin’s lymphoma – diagnosis and treatment. Lancet Oncol 5:19–26CrossRefPubMedGoogle Scholar
  4. Meyer RM, Gospodarowicz MK, Connors JM et al (2005) Randomized comparison of ABVD chemotherapy with a strategy that includes radiation therapy in patients with limited-stage Hodgkin’s lymphoma: National Cancer Institute of Canada Clinical Trials Group and the Eastern Cooperative Oncology Group. J Clin Oncol 23:4634–4642CrossRefPubMedGoogle Scholar
  5. Straus DJ, Portlock CS, Qin J et al (2004) Results of a prospective randomized clinical trial of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by radiation therapy (RT) versus ABVD alone for stages I, II, and IIIA nonbulky Hodgkin disease. Blood 104:3483–3489CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Lymphoma Service, Department of MedicineMemorial Sloan Kettering Cancer CenterNew YorkUSA