Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

DNA Damage Tolerance

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1671-2

Synonyms

Definition

DNA damage tolerance is a biological mechanism in response to DNA damage which overcomes arrested DNA replication as a result of unrepaired DNA damage, leading to elimination of its potential lethal effects.

Characteristics

DNA is frequently damaged by endogenous and environmental factors. Base damage in DNA template strands blocks transcription to allow time to activate transcription-coupled repair pathways and eliminate DNA base damage. However, some lesions are persistent during replication therefore causing replication blockage and cell death. In order to overcome this problem, cells have evolved a damage tolerance system to allow complete replication in the presence of DNA damage. This process bypasses, rather removes, DNA damage, therefore, it is also named replicative bypass. It enables the cell to tolerate DNA damage and promote cell survival at the expense of high mutation rate. In...

Keywords

Translesion Synthesis Lesion Bypass Correct Nucleotide Flexible Active Site Replicative Bypass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Cleaver JE (2005) Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nature 5:564–573Google Scholar
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  5. Wang Z (2001) DNA damage-induced mutagenesis: a novel target for cancer prevention. Mol Interv 1:269–281PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of AnatomyThe University of Hong KongHong KongChina