Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

DLC1

  • Judy W. P. Yam
  • Chun-Ming Wong
  • Irene O. L. Ng
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1656-2

Synonyms

Definition

DLC1 is a tumor suppressor gene frequently underexpressed in various types of cancers. Genomic deletion and promoter hypermethylation may account for the inactivation of DLC1 in human cancers. Functionally, overexpression of DLC1 can result in the tumor suppression in cancer cells and regulation of cytoskeleton organization.

Characteristics

Deleted in liver cancer 1 ( DLC1), also known as Rho- GTPase -activating protein 7 ( ARHGAP7) and START domain- containing protein ( STARD12), is a putative tumor suppressor gene identified from primary hepatocellular carcinoma (HCC) in 1998. Human DLC1 gene was mapped to chromosome region 8p21.3–22. The full-length DLC1 mRNA is 6 kb long and consists of 14 exons which encode a protein of 1,091 amino acids. In silico analysis indicated that DLC1 shares 86 % sequence homology with rat p122 RhoGAPand is likely to be its human...

Keywords

Stress Fiber Formation Sterile Alpha Motif Growth Suppressive Effect Actin Stress Fiber Formation Established Cancer Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Ng IOL, Liang ZD, Cao L et al (2000) DLC1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC1. Cancer Res 60:6581–6584PubMedGoogle Scholar
  2. Wong CM, Lee JMF, Ching YP et al (2003) Genetic and epigenetic alterations of DLC1 gene in hepatocellular carcinoma. Cancer Res 63:7646–7651PubMedGoogle Scholar
  3. Wong CM, Yam JWP, Ching YP et al (2005) Rho GTPase activating protein DLC1 (deleted in liver cancer) suppresses cell proliferation and invasion in hepatocellular carcinoma. Cancer Res 65:8861–8868CrossRefPubMedGoogle Scholar
  4. Yam JWP, Ko FCF, Chan CY et al (2006) Interaction of DLC1-tensin2 complex with caveolin-1 and implications in tumor suppression. Cancer Res 66:8367–8372CrossRefPubMedGoogle Scholar
  5. Yuan BZ, Miller MJ, Keck CL et al (1998) Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC1) homologous to rat RhoGAP. Cancer Res 58:2196–2199PubMedGoogle Scholar

See Also

  1. (2012) Actin cytoskeleton. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 19. doi:10.1007/978-3-642-16483-5_43Google Scholar
  2. (2012) Caveolae. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 682. doi:10.1007/978-3-642-16483-5_894Google Scholar
  3. (2012) DNA methylation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1140. doi:10.1007/978-3-642-16483-5_1682Google Scholar
  4. (2012) Homozygous deletion. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1729. doi:10.1007/978-3-642-16483-5_2807Google Scholar
  5. (2012) Knock-out mouse. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1957. doi:10.1007/978-3-642-16483-5_3239Google Scholar
  6. (2012) Loss of heterozygosity. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2075-2076. doi:10.1007/978-3-642-16483-5_3415Google Scholar
  7. (2012) Nude mice. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2584. doi:10.1007/978-3-642-16483-5_4172Google Scholar
  8. (2012) Promoter. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3004. doi:10.1007/978-3-642-16483-5_4768Google Scholar
  9. (2012) Promoter hypermethylation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3004. doi:10.1007/978-3-642-16483-5_4769Google Scholar
  10. (2012) Single nucleotide polymorphism. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3412. doi:10.1007/978-3-642-16483-5_5316Google Scholar
  11. (2012) Tensin2. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3647. doi:10.1007/978-3-642-16483-5_5726Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Judy W. P. Yam
    • 1
  • Chun-Ming Wong
    • 1
  • Irene O. L. Ng
    • 1
  1. 1.Department of PathologyThe University of Hong KongHong KongChina