Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Diffuse Large B-Cell Lymphoma

Living reference work entry

Later version available View entry history

DOI: https://doi.org/10.1007/978-3-642-27841-9_1618-2

Synonyms

Definition

Diffuse large B-cell lymphoma is a non-Hodgkin lymphoma entity composed of malignant large lymphoid cells with blastic morphologic features, expression of B-cell markers, and with a diffuse growth pattern. The postulated cells of origin are germinal or postgerminal center B-cells. This lymphoma entity is morphologically, clinically, and genetically heterogeneous.

Characteristics

Diffuse large B-cell lymphoma is the most common type of lymphoma comprising 30–40 % of adult non-Hodgkin lymphomas and approximately 20 % of non-Hodgkin lymphomas in childhood and adolescence. Diffuse large B-cell lymphoma can be seen in all age groups, but the incidence increases with age. The median age at diagnosis is approximately 65 years. There is a slight male preponderance. In most patients the tumor resides in...

Keywords

Chronic Lymphocytic Leukemia Follicular Lymphoma International Prognostic Index Anaplastic Large Cell Lymphoma Primary Effusion Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Armitage JO, Mauch PM, Harris NL et al (2004) Diffuse large B-cell lymphoma. In: Mauch PM, Armitage JO, Coiffier B, Dalla-Favera R, Harris NL (eds) Non-Hodgkin’s lymphomas. Lippincott Williams & Wilkins, Philadelphia, pp 427–453Google Scholar
  2. Gatter KC, Warnke RJ (2001) Diffuse large B-cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) World Health Organization classification of tumours. Pathology and genetics. Tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 171–174Google Scholar
  3. Küppers R (2005) Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 5:251–262CrossRefPubMedGoogle Scholar
  4. Møller MB, Pedersen NT, Christensen BE (2004) Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation – a population-based study of 1575 cases. Br J Haematol 124:151–159CrossRefPubMedGoogle Scholar
  5. Staudt LM, Dave S (2005) The biology of human lymphoid malignancies revealed by gene expression profiling. Adv Immunol 87:163–208CrossRefPubMedPubMedCentralGoogle Scholar

See Also

  1. (2012) B Symptoms. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 331. doi:10.1007/978-3-642-16483-5_511Google Scholar
  2. (2012) BCL-6. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 363–364. doi:10.1007/978-3-642-16483-5_566Google Scholar
  3. (2012) Bulky. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 574. doi:10.1007/978-3-642-16483-5_752Google Scholar
  4. (2012) CD20. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 693. doi:10.1007/978-3-642-16483-5_922Google Scholar
  5. (2012) CD30. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 697. doi:10.1007/978-3-642-16483-5_926Google Scholar
  6. (2012) CD95. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 703. doi:10.1007/978-3-642-16483-5_939Google Scholar
  7. (2012) Class Switching. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 879. doi:10.1007/978-3-642-16483-5_1203Google Scholar
  8. (2012) Doxorubicin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1159. doi:10.1007/978-3-642-16483-5_1722Google Scholar
  9. (2012) Germinal Center. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1541. doi:10.1007/978-3-642-16483-5_2401Google Scholar
  10. (2012) Immunoglobulin Genes. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1819. doi:10.1007/978-3-642-16483-5_2992Google Scholar
  11. (2012) Ki-67. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1943. doi:10.1007/978-3-642-16483-5_3213Google Scholar
  12. (2012) Non-Hodgkin Lymphoma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2537. doi:10.1007/978-3-642-16483-5_4110Google Scholar
  13. (2012) Prednisone. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2972. doi:10.1007/978-3-642-16483-5_4720Google Scholar
  14. (2012) Somatic Hypermutation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3466–3467. doi:10.1007/978-3-642-16483-5_5410Google Scholar
  15. (2012) Vincristine. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3908. doi:10.1007/978-3-642-16483-5_6188Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PathologyOdense University HospitalOdenseDenmark