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Deleted in Malignant Brain Tumors 1

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Encyclopedia of Cancer

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Synonyms

Apactin (mouse); CRP-ductin (mouse); DMBT1; Ebnerin (rat); Glycoprotein-340 (gp-340 human); H3 (rhesus monkey); Hensin (rabbit); Muclin (mouse); Salivary agglutinin (SAG, human); Vomeroglandin (mouse)

Definition

DMBT1 located at chromosome 10q26.13 2 was initially identified as a gene that shows frequent homozygous deletions in malignant brain tumors. It codes for an extracellular glycoprotein of the evolutionary highly conserved group of scavenger receptor cysteine-rich (SRCR) proteins, and it is widely expressed in human tissues with strongest expression in epithelia and associated glands. Based on genomic alterations and loss of expression in several cancer types, DMBT1 has been proposed to play a role in tumorigenesis. The currently available data suggests two physiological functions for DMBT1: a function in innate immunity/mucosal protection and a function in epithelial/stem cell differentiation and regenerative processes.

Characteristics

The human DMBT1-locus is built up...

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References

  • Kang W, Reid KBM (2003) DMBT1 a regulator of mucosal homeostasis through the linking of mucosal defence and regeneration? FEBS Lett 540(1–3):21–25

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  • Mollenhauer J, Wiemann S, Scheurlen W et al (1997) DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-q26.1 is deleted in malignant brain tumours. Nat Genet 17:32–39

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Author information

Authors and Affiliations

  1. Division of Molecular Genome Analysis, DKFZ, Heidelberg, Germany

    Caroline End, Marcus Renner & Annemarie Poustka

  2. Molecular Oncology Group, University of Southern Denmark, Odense, Denmark

    Jan Mollenhauer

Authors
  1. Caroline End
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  2. Marcus Renner
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  3. Jan Mollenhauer
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  4. Annemarie Poustka
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Corresponding author

Correspondence to Caroline End .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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End, C., Renner, M., Mollenhauer, J., Poustka, A. (2015). Deleted in Malignant Brain Tumors 1. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1551-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1551-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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