Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Deleted in Malignant Brain Tumors 1

  • Caroline End
  • Marcus Renner
  • Jan Mollenhauer
  • Annemarie Poustka
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1551-2

Synonyms

Definition

DMBT1 located at chromosome 10q26.13 2 was initially identified as a gene that shows frequent homozygous deletions in malignant brain tumors. It codes for an extracellular glycoprotein of the evolutionary highly conserved group of scavenger receptor cysteine-rich (SRCR) proteins, and it is widely expressed in human tissues with strongest expression in epithelia and associated glands. Based on genomic alterations and loss of expression in several cancer types, DMBT1 has been proposed to play a role in tumorigenesis. The currently available data suggests two physiological functions for DMBT1: a function in innate immunity/mucosal protection and a function in epithelial/stem cell differentiation and regenerative processes.

Characteristics

The human DMBT1-locus is built up...

Keywords

Pancreatic Cancer Homozygous Deletion Genomic Alteration Malignant Brain Tumor Pathogen Defense 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Kang W, Reid KBM (2003) DMBT1 a regulator of mucosal homeostasis through the linking of mucosal defence and regeneration? FEBS Lett 540(1–3):21–25CrossRefPubMedGoogle Scholar
  2. Mollenhauer J, Wiemann S, Scheurlen W et al (1997) DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-q26.1 is deleted in malignant brain tumours. Nat Genet 17:32–39CrossRefPubMedGoogle Scholar
  3. Mollenhauer J, Holmskov U, Wiemann S et al (1999) The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability. Oncogene 18:6233–6240CrossRefPubMedGoogle Scholar
  4. Mollenhauer J, Helmke B, Muller H et al (2002) An integrative model on the role of DMBT1 in epithelial cancer. Cancer Detect Prev 26(4):266–274CrossRefPubMedGoogle Scholar
  5. Vijayakumar S, Takito J, Gao X et al (2006) Differentiation of columnar epithelia: the hensin pathway. J Cell Sci 119(Pt 23):4797–4801CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Caroline End
    • 1
  • Marcus Renner
    • 1
  • Jan Mollenhauer
    • 2
  • Annemarie Poustka
    • 1
  1. 1.Division of Molecular Genome Analysis, DKFZHeidelbergGermany
  2. 2.Molecular Oncology GroupUniversity of Southern DenmarkOdenseDenmark