Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

DNA Damage Response Genes

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1510-6

Definition

DNA damage response genes encompass all genes that encode proteins required for either direct or indirect response to DNA damage. The proteins encoded by these genes either act to help repair the damaged DNA within replicating cells or if damage is sufficient, to activate cell cycle checkpoints and if too severe, to activate cell death pathways. Each of the above enzymatic pathways also includes posttranslational modifiers such as protein kinases, phosphorylases, ubiquitin ligases, acetylators, sumoylators, methylators, scaffolding proteins required for proteasome complexes, and epigenetic gene silencing pathways. MicroRNA-mediated transcriptional regulation will likely be included in the future, as more information is gathered about this gene regulation system. The number of individual pathways and genetic sequences contributing to the major pathways above are unknown but likely encompass several 100 or more.

Characteristics

This essay will focus primarily on mutated genes...

Keywords

Nucleotide Excision Repair Base Excision Repair Fanconi Anemia Xeroderma Pigmentosum Werner Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Fu D, Calvo JA, Samson LD (2012) Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer 12:104–120PubMedCentralPubMedGoogle Scholar
  2. Lahtz C, Pfeifer GP (2011) Epigenetic changes of DNA repair genes in cancer. J Mol Biol 3:51–58Google Scholar
  3. Lange SS, Takata K-I, Wood RC (2011) DNA polymerases and cancer. Nat Rev Cancer 11:96–110PubMedCentralCrossRefPubMedGoogle Scholar
  4. Polo SE, Jackson SP (2011) Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev 25:409–433PubMedCentralCrossRefPubMedGoogle Scholar
  5. Stratton MR (2011) Exploring the genomes of cancer cells: progress and promise. Science 331:1553–1558CrossRefPubMedGoogle Scholar

See Also

  1. (2012) ATR. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 302. doi:10.1007/978-3-642-16483-5_443Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Biochemistry and Cancer Biology, Health Science CampusUT College of MedicineToledoUSA