Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Chronic Lymphocytic Leukemia

  • Jesper Jurlander
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1153-2

Synonyms

CLL

Definition

CLL is a chronic form of leukemia with accumulation of small mature B lymphocytes that express the surface membrane proteins CD5, CD19, and CD23.

Characteristics

Diagnosis

A diagnosis of CLL requires persistent absolute B lymphocytosis of 5 × 109/l or more, with a characteristic immunophenotype and cytomorphology. Usually the diagnosis can be made based on a blood sample. In the identical lymphoma disorder, small lymphocytic lymphoma, the level of circulating tumor cells in the blood and bone marrow may be very low or absent. The diagnosis of SLL therefore may require a lymph node biopsy.

Epidemiology

CLL is the most common leukemia in the Western world, with an incidence of approximately 5 new cases per 100,000 persons per year. The median age at diagnosis is 70 years, and the incidence increases with age. CLL may be seen in younger adults but never in children.

Etiology

The causes of CLL are largely unknown. Unlike other leukemias, there is no relation to...

Keywords

Chronic Lymphocytic Leukemia Bone Marrow Failure Allogeneic Hematopoietic Cell Transplantation Clinical Staging System Progressive Bone Marrow Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

  1. (2012) Alemtuzumab. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 127. doi:10.1007/978-3-642-16483-5_177Google Scholar
  2. (2012) CD52. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 702. doi:10.1007/978-3-642-16483-5_932Google Scholar
  3. (2012) Cytogenetics. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 1050–1051. doi:10.1007/978-3-642-16483-5_1470Google Scholar
  4. (2012) Graft-versus-host disease. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1597. doi:10.1007/978-3-642-16483-5_2502Google Scholar
  5. (2012) Immunoglobulin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1819. doi:10.1007/978-3-642-16483-5_2990Google Scholar
  6. (2012) Non-myeloablative. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2538. doi:10.1007/978-3-642-16483-5_4116Google Scholar
  7. (2012) Thrombocytopenia. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3678. doi:10.1007/978-3-642-16483-5_5792Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Jesper Jurlander
    • 1
  1. 1.Department of HematologyRigshospitaletCopenhagenDenmark