Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Chemoradiotherapy

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_1074-3

Synonyms

Definition

Chemoradiotherapyrefers to the combination of a cytostatic drug and external beam irradiation and can be applied sequentially or concurrently. There are several arguments to combine both modalities. While radiotherapy is aimed at controlling the primary tumor, chemotherapy is used to eradicate distant (micro-) metastases (spatial cooperation). Both modalities may be active against different tumor cell populations (independent cell-killing effect). In addition, chemotherapy may synchronize cells in a vulnerable phase for radiotherapy, decrease repopulation after radiotherapy, and enhance reoxygenation. It was also thought that shrinking a tumor with chemotherapy first should be advantageous for radiotherapy. However, this concept has failed in most clinical trials, probably due to fast repopulation of tumor cells after cytoreduction with chemotherapy before the start of radiotherapy. In...

Keywords

Epidermal Growth Factor Receptor Cervical Cancer Esophageal Cancer Total Mesorectal Excision Preoperative Radiotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Bartelink H, Schellens JHM, Verheij M (2002) The combined use of radiotherapy and chemotherapy in the treatment of solid tumors. Eur J Cancer 38:216–222PubMedCrossRefGoogle Scholar
  2. Hennequin C, Favaudon V (2002) Biological basis for chemo-radiotherapy interactions. Eur J Cancer 38:223–230PubMedCrossRefGoogle Scholar
  3. John MJ (2004) Radiotherapy and chemotherapy. In: Leibel SA, Phillips TL (eds) Textbook of radiation oncology, 2nd edn. Saunders, Philadelphia, pp 77–100Google Scholar
  4. Stewart FA, Bartelink H (2002) The combination of radiotherapy and chemotherapy. In: Steel GG (ed) Basic clinical radiobiology, 3rd edn. Hodder Arnold, London, pp 217–230Google Scholar
  5. Tannock IF (1996) Treatment of cancer with radiation and drugs. J Clin Oncol 14:3156–3174PubMedGoogle Scholar
  6. Verheij M, Vens C, van Triest B (2010) Novel therapeutics in combination with radiotherapy to improve cancer treatment: rationale, mechanisms of action and clinical perspective. Drug Resist Updat 13:29–43PubMedCrossRefGoogle Scholar

See Also

  1. (2012) Adjuvant. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 75. doi:10.1007/978-3-642-16483-5_107Google Scholar
  2. (2012) Anti-angiogenic drugs. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 207–208. doi:10.1007/978-3-642-16483-5_302Google Scholar
  3. (2012) Carboplatin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 641. doi:10.1007/978-3-642-16483-5_833Google Scholar
  4. (2012) Concurrent. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 965. doi:10.1007/978-3-642-16483-5_6821Google Scholar
  5. (2012) EGFR. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1211. doi:10.1007/978-3-642-16483-5_1828Google Scholar
  6. (2012) Epirubicin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1291. doi:10.1007/978-3-642-16483-5_1955Google Scholar
  7. (2012) Leucovorin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2005. doi:10.1007/978-3-642-16483-5_3321Google Scholar
  8. (2012) Neoadjuvant. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2472. doi:10.1007/978-3-642-16483-5_4003Google Scholar
  9. (2012) 6,4-Photoproduct. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2881. doi:10.1007/978-3-642-16483-5_4557Google Scholar
  10. (2012) VEGF. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3906. doi:10.1007/978-3-642-16483-5_6174Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of RadiotherapyThe Netherlands Cancer Institute–Antoni van Leeuwenhoek HospitalAmsterdamThe Netherlands