Skin Itch in the Elderly

Living reference work entry


Itching is generally known as pruritus. It is a normal reflex and common in the elderly. Aside from causes such as insect stings and contact with certain marine animals, there are other common causes that can be dermatologic, neuropathic, systemic, and psychogenic. The itch reflex is a complex reflex involving separate receptors on sensory neurons that are similar but distinct from pain sensory fibers in the skin. The receptors can be triggered by histamine, G protein receptors, proteases, and toll-like receptors, through TRPV1, TRPV3, and TRPV4 vanilloid receptors on sensory nerves, gastrin, and serotonin, to mention just a few of the stimuli that can trigger itch. The most common of these is histamine. When the skin is inflamed, as histamine is released, it triggers the itch response. In the elderly, chronic itching can interfere with the quality of life. When caused by organ failure or necessary medications such as medications for pain, it offers a quandary – stop the pain medications and increase pain or suffer with chronic itch. This chapter describes the reflex, itching in the elderly, and therapeutic interventions to reduce itch in the elderly.


Itch Pruritus Histamine Itch reflex 


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Authors and Affiliations

  1. 1.School of Allied HealthLoma Linda UniversityLoma LindaUSA

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