Tick vaccines became commercially available in the early 1990s for the control of cattle tick infestations (especially in Australia). Most of them are derived from the midgut of the one-host tick Boophilus microplus (BM86). Several BM86 orthologs and homologs have been identified in Boophilus annulatus (BA86) and Hyalomma anatolicum anatolicum (HAA86) and in B. microplus (BM95). Several salivary gland antigens have also been described, e.g.:
64TRP is a tick protein of Rhipicephalus appendiculatus.
Salp25D is expressed by Ixodes scapularis.
THRF (tick histamine release) is also produced by Ixodes scapularis and apparently important in Borrelia transmission.
TSLPI (tick salivary lectin pathway inhibitor) is produced by Ixodes scapularis.
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Further Reading
Estrada-Pena A, Salman M (2013) Current limitations in the control and spread of ticks that affect livestock. Agriculture 72:221–235
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Mehlhorn, H. (2015). Tick Antigens. In: Mehlhorn, H. (eds) Encyclopedia of Parasitology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27769-6_5004-1
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DOI: https://doi.org/10.1007/978-3-642-27769-6_5004-1
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Publisher Name: Springer, Berlin, Heidelberg
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