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Sulfadoxine Pyrimethamine Resistance

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Encyclopedia of Parasitology

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This compound is used in Africa for intermittent preventive therapy in pregnant women (IPTp) and infants (IPTi). The resistance of some Plasmodium falciparum strains against a treatment with sulfadoxine pyrimethamine is due to the fact that resistant strains show a mutation in the genes Pfdhfr (P. falciparum dihydrofolate reductase) and Pfdhps (P. falciparum dihydropteroate synthase). These apparently progressing resistances endanger any mass treatment. In three foci of East Africa the populations are already fully resistant.

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Further Reading

  • Naidoo I, Roper C (2013) Mapping partially resistant, fully resistant, and super resistant malaria. Trends Parasitol 29:505–515

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  • Venkatesan M et al (2013) Monitoring antifolate resistance in intermittent preventive therapy for malaria. Trends Parasitol 29:497–504

    Article  CAS  PubMed  Google Scholar 

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  1. Institut für Zoomorphologie, Zellbiologie und Parasitologie, Heinrich-Heine-Universität, Universitätsstraße 1, 40225, Düsseldorf, Germany

    Heinz Mehlhorn

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  1. Heinz Mehlhorn
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Correspondence to Heinz Mehlhorn .

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Editors and Affiliations

  1. Institute of Zoomorphology and Parasitology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

    Heinz Mehlhorn

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Mehlhorn, H. (2015). Sulfadoxine Pyrimethamine Resistance. In: Mehlhorn, H. (eds) Encyclopedia of Parasitology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27769-6_4358-1

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  • DOI: https://doi.org/10.1007/978-3-642-27769-6_4358-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27769-6

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