Macrocyclic lactone (16-membered macrocyclic lactone, avermectins).
Mode of Action
Glutamate-gated chloride channel modulator. Nematocidal Drugs, Ectoparasiticides: Antagonists and Modulators of Chloride Channels.
Ivermectin application increases the release of GABA (γ-aminobutyric acid) at the presynaptic nerve ending leading to the opening of the chloride ion channels and thus increasing the GABA binding at the motor neuron.
KeywordsMotor Neuron Chloride Channel Chemical Class Channel Modulator Macrocyclic Lactone
- Dourmishew AL et al (2005) Ivermectin: pharmacology and application in dermatology. Int J Dermatol 44:1981–1988Google Scholar