Cell Patterning on Chip
Synonyms
Definition
Cell patterning is a process to position cells on a substrate, especially in a microfluidic chip, with defined spatial selection and in turn to keep stable cell growth on the substrate.
Overview
Predefined patterning or network of cells is important for cellular/tissue function and neuronal activities. Cell patterning has a wide range of applications such as tissue engineering, wound healing, biosensors, and cell migration studies.
Early studies for patterning cells were reported in 1914 [1] in which the interaction between spiders’ webs and embryonic cells was studied. Similarly, other artificial microstructures used for cell patterning have been reported. These structures include grooved structures, micro-stamps, and micro-agarose chambers. Another approach is to use patterned surface coatings, e.g., metal, self-assembled monolayer, protein, or other chemicals, to guide cell growth. These coatings either promote or inhibit cell...
References
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