Encyclopedia of Microfluidics and Nanofluidics

Living Edition
| Editors: Dongqing Li

Optical Detection on Centrifugal Microfluidic Lab-on-a-disc Platforms

  • Damien King
  • Jens Ducrée
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27758-0_1785-1



The centrifugal microfluidic platforms utilize primarily the rotationally controlled centrifugal field in combination with capillary forces to network a range of laboratory unit operations (LUOs) such as metering, aliquoting, mixing, and extraction for biofluids as well as sorting, isolation, and counting of bioparticles to integrate and automate bioanalytical assay protocols. Due to its evident technological analogies to optical disc drive (ODD) technologies such as a compact disc (CD) or digital versatile disc (DVD) and due to its high sensitivity, specificity, and ease of integration with a low-footprint, rugged, and essentially maintenance-free instrument, optical detection techniques have been the mainstay for readout of “lab-on-a-disc” (LoaD) systems. This chapter surveys the repertoire of optical sensing...

This is a preview of subscription content, log in to check access.


  1. 1.
    Pohlmann KC (1992) The compact disc handbook, 2nd edn. A-R Editions, MadisonGoogle Scholar
  2. 2.
    Grumann M, Steigert J, Riegger L, Moser I, Enderle B, Urban G, Zengerle R, Ducrée J (2006) Sensitivity enhancement for colorimetric glucose assays on whole blood by on-chip beam-guidance. Biomed Microdevices 8(3):209–214CrossRefGoogle Scholar
  3. 3.
    Hoffmann J, Riegger L, Bundgaard F, Mark D, Zengerle R, Ducrée J (2012) Optical non – contact localization of liquid – gas interfaces on disk during rotation for measuring flow rates and viscosities. Lab Chip 12:5231–5236CrossRefGoogle Scholar
  4. 4.
    Biosurfit (Lisbon, Portugal). http://www.biosurfit.com/
  5. 5.
    Gyros AB (Uppsala, Sweden). http://www.gyros.com/
  6. 6.
    Lee BS, Lee JN, Park JM, Lee JG, Kim S, Cho YK, Ko C (2009) A fully automated immunoassay from whole blood on a disc. Lab Chip 9:1548–1555CrossRefGoogle Scholar
  7. 7.
    Grumann M, Brenner T, Beer C, Zengerle R, Ducrée J (2005) Visualization of flow patterning in high-speed centrifugal microfluidics. Rev Sci Instrum 76(2):025101CrossRefGoogle Scholar
  8. 8.
    Nolte DD (2009) Review of centrifugal microfluidic and bio-optical disks. Rev Sci Instrum 80:101101CrossRefGoogle Scholar
  9. 9.
    Imaad SM, Lord N, Kulsharovaa G, Liu GL (2011) Microparticle and cell counting with digital microfluidic compact disc using standard CD drive. Lab Chip 11:1448–1456CrossRefGoogle Scholar
  10. 10.
    Ramachandraiah H, Amasia M, Cole J, Sheard P, Pickhaver S, Walker C, Wirta V, Lexow P, Lione R, Russom A (2013) Lab-on-DVD: standard DVD drives as a novel laser scanning microscope for image based point of care diagnostics. Lab Chip 13:1578–1585CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Biomedical Diagnostics Institute (BDI), National Centre for Sensor ResearchSchool of Physical Sciences, Dublin City UniversityDublinIreland