Experimental Cataract Formation

Living reference work entry

Abstract

A is a clouding of thelens inside the eye which leads to a decrease in vision. It is the most common cause of blindness and is conventionally treated with surgery. Visual loss occurs because opacification of the lens obstructs light from passing and being focused on the retina at the back of the eye.

Keywords

Sodium Selenite Cataract Formation Lens Opacification Posterior Subcapsular Cataract Nuclear Cataract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References and Further Reading

  1. Anderson RS, Trune DR, Shearer TR (1988) Histologic changes in selenite cortical cataract. Invest Ophthalmol Vis Sci 29:1418–1427. [HYPERLINK “/pubmed/3417427”PubMed]Google Scholar
  2. Babizhayev MA, Guiotto A, Kasus-Jacobi A (2009) N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications. J Drug Target 17:36–63PubMedCrossRefGoogle Scholar
  3. Biju PG, Rooban BN, Lija Y, Devi VG, Sahasranamam V, Abraham A (2007a) Drevogenin D prevents selenite-induced oxidative stress and calpain activation in cultured rat lens. Mol Vis 3:1121–1129Google Scholar
  4. Biju PG, Devi VG, Lija Y, Abraham A (2007b) Protection against selenite cataract in rat lens by drevogenin D, a triterpenoid aglycone from Dregea volubilis. J Med Food 10:308–315PubMedCrossRefGoogle Scholar
  5. Cenedella RJ (1998) Prenylation of proteins by the intact lens. Invest Ophthalmol Vis Sci 39:1276–1280PubMedGoogle Scholar
  6. Chandra D, Ramana KV, Wang L, Christensen BN, Bhatnagar A, Srivastava SK (2002) Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin. Invest Ophthalmol Vis Sci 43:2285–2292PubMedGoogle Scholar
  7. Chandrasekher G, Cenedella RJ (1993) Calcium activated proteolysis and protein modification in the U18666A cataract. Exp Eye Res 57:737–745PubMedCrossRefGoogle Scholar
  8. Cheng HM (2002) Water diffusion in the rabbit lens in vivo. Dev Ophthalmol 35:169–175PubMedCrossRefGoogle Scholar
  9. David LL, Shearer TR, Shih M (1993) Sequence analysis of lens β-crystallins suggests involvement of calpain in cataract formation. J Biol Chem 268:1937–1940PubMedGoogle Scholar
  10. David LL, Azuma M, Shearer TR (1994) Cataract and the acceleration of calpain-induced β-crystallin insolubilization occurring during normal maturation of rat lens. Invest Ophthalmol Vis Sci 35:785–793PubMedGoogle Scholar
  11. Descamps FJ, Martens E, Proost P, Starckx S, van den Steen PE, van Damme J, Opdenakker G (2005) Gelatinase B/matrix metalloproteinase-9 provokes cataract by cleaving lens βB1-crystallin. FASEB J 19:29–35PubMedCrossRefGoogle Scholar
  12. Devamanoharan PS, Varma SD (1995) Inhibition of polyol formation in rat lens by verapamil. J Ocul Pharmacol Ther 11:527–531PubMedCrossRefGoogle Scholar
  13. Dickerson JE, Lou MF, Gracy RW (1995) The culture of rat lenses in high sugar media: effect on mixed disulfide levels. Curr Eye Res 14:109–118PubMedCrossRefGoogle Scholar
  14. Dickerson JE Jr, Dotzel E, Clark AF (1997) Steroid-induced cataract: new perspective from in vitro and lens culture studies. Exp Eye Res 65:507–516PubMedCrossRefGoogle Scholar
  15. Dillon J, Roy D, Spector A, Walker ML, Hibbard LB, Borkman RF (1989) UV laser photodamage to whole lenses. Exp Eye Res 49:959–966PubMedCrossRefGoogle Scholar
  16. Doganay S, Turkoz Y, Evereklioglu C, Er H, Bozaran M, Ozerol E (2002) Use of caffeic acid phenethyl ester to prevent sodium selenite-induced cataract in rat eyes. J Cataract Refract Surg 28:1457–1462PubMedCrossRefGoogle Scholar
  17. Fris M, Tessem MB, Sather O, Midelfart A (2006) Biochemical changes in selenite cataract model measured by high-resolution MAS (1)H NMR spectroscopy. Acta Ophthalmol Scand 84:684–692PubMedCrossRefGoogle Scholar
  18. Fujii N, Takeuchi N, Fujii N, Tezuka T, Kuge K, Takata T, Kamei A, Saito T (2004) Comparison of post-translational modifications of αA-crystallin from normal and hereditary cataract rats. Amino Acids 26:147–152PubMedCrossRefGoogle Scholar
  19. Fukiage C, Azuma M, Nakamura Y, Tamada Y, Nakamura M, Shearer TR (1997) SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: amelioration of cataract in cultured rat lenses. Biochim Biophys Acta 1361:304–312PubMedCrossRefGoogle Scholar
  20. Ghosh MP, Zigler JS (2005) Lack of fiber cell induction stops normal growth of rat lenses in organ culture. Mol Vis 11:901–908PubMedGoogle Scholar
  21. Gift BW, English RV, Nadelstein B, Weigt AK, Gilger BC (2009) Comparison of capsular opacification and refractive status after placement of three different intraocular lens implants following phacoemulsification and aspiration of cataracts in dogs. Vet Ophthalmol 12:13–21PubMedCrossRefGoogle Scholar
  22. Groenen PJ, Grootjans JJ, Lubsen NH, Bloemendal H, de Jong WW (1994) Lys-17 is the amine-donor substrate site for transglutaminase in βA3-crystallin. J Biol Chem 269:831–833PubMedGoogle Scholar
  23. Hales AM, Chamberlain CG, McAvoy JW (1995) Cataract induction in lenses cultured with transforming-growth-factor- β. Invest Ophthalmol Vis Sci 36:1709–1713PubMedGoogle Scholar
  24. Huang LL, Hess JL, Bunce GE (1990a) DNA damage, repair and replication in selenite-induced cataract in rat lens. Curr Eye Res 9:1041–1050PubMedCrossRefGoogle Scholar
  25. Huang WQ, Zhang JP, Fu JSC (1990b) Differential effects of galactose-induced cataractogenesis on the soluble crystallins of rat lens. Exp Eye Res 51:79–85PubMedCrossRefGoogle Scholar
  26. Huang LL, Zhang C-Y, Hess JL, Bunce GE (1992) Biochemical changes and cataract formation in lenses from rats receiving multiple, low doses of sodium selenite. Exp Eye Res 55:671–678PubMedCrossRefGoogle Scholar
  27. Huang FY, Ho Y, Shaw TS, Chuang SA (2000) Functional and structural studies of α-crystallin from galactosemic rat lenses. Biochem Biophys Res Commun 273:197–202PubMedCrossRefGoogle Scholar
  28. Ito H, Iida K, Kamei K, Iwamoto I, Inaguma Y, Kato K (1999) αB-crystallin in the rat lens is phosphorylated at an early post-natal age. FEBS Lett 446:269–272PubMedCrossRefGoogle Scholar
  29. Kador PF, Takahashi Y, Akagi Y, Blessing K, Randazzo J, Wyman M (2007) Age dependent retinal capillary pericyte degeneration in galactose-fed dogs. J Ocul Pharmacol Ther 23:63–69PubMedCrossRefGoogle Scholar
  30. Kinoshita JH (1974) Mechanisms initiating cataract formation. Proctor Lecture. Invest Ophthalmol 13:713–724PubMedGoogle Scholar
  31. Kuck JFR Jr (1970) Clinical constituents of the lens, metabolism of the lens, cataract formation. In: Graymore CN (ed) Biochemistry of the eye. Academic, New York, pp 183–371Google Scholar
  32. Kumar PA, Haseeb A, Suryanarayana P, Ehtesham NZ, Reddy GB (2005a) Elevated expression of αA- and αB-crystallins in streptozotocin-induced diabetic rat. Arch Biochem Biophys 444:77–83PubMedCrossRefGoogle Scholar
  33. Kumar PA, Suryanarayana P, Reddy PY, Reddy GB (2005b) Modulation of α-crystallin chaperone activity in diabetic rat lens by curcumin. Mol Vis 11:561–568PubMedGoogle Scholar
  34. Kyselova Z (2010) Slovak Toxicology Society SETOX & Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, different experimental approaches in modelling cataractogenesis, an overview of selenite-induced nuclear cataract in rats. Interdiscip Toxicol 3(1):3–14PubMedCentralPubMedCrossRefGoogle Scholar
  35. Kyselova Z, Garcia SJ, Gajdosikova A, Gajdosik A, Stefek M (2005a) Temporal relationship between lens protein oxidation and cataract development in streptozotocin-induced diabetic rats. Physiol Res 54:49–56PubMedGoogle Scholar
  36. Kyselova Z, Gajdosik A, Gajdosikova A, Ulicna O, Mihalova D, Karasu C, Stefek M (2005b) Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. Mol Vis 11:56–65PubMedGoogle Scholar
  37. Kyselova Z, Krizanova L, Soltes L, Stefek M (2005c) Electrophoretic analysis of oxidatively modified eye lens proteins in vitro: implications for diabetic cataract. J Chromatogr A 1084:95–100PubMedCrossRefGoogle Scholar
  38. Lampi KJ, Shih M, Ueda Y, Shearer TR, David LL (2002) Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map. Invest Ophthalmol Vis Sci 43:216–224PubMedGoogle Scholar
  39. Lee AY, Chung SS (1998) Involvement of aldose reductase in naphthalene cataract. Invest Ophthalmol Vis Sci 39:193–197PubMedGoogle Scholar
  40. Lou MF, Xu GT, Cui XL (1995) Further studies on the dynamic changes of glutathione and protein-thiol mixed disulfides in H2O2-induced cataract in rat lenses: distributions and effect of aging. Curr Eye Res 14:951–958PubMedCrossRefGoogle Scholar
  41. Manikandan R, Thiagarajana R, Beulaja S, Chindhud S, Mariammale K, Sudhandiranc G, Arumugama M (2009) Anti-cataractogenic effect of curcumin and aminoguanidine against selenium-induced oxidative stress in the eye lens of Wistar rat pups: an in vitro study using isolated lens. Chem Biol Interact 181:202–209PubMedCrossRefGoogle Scholar
  42. Mitton KP, Linklater HA, Dzialoszynski T, Sanford SE, Starkey K, Trevithick JR (1999) Modelling cortical cataractogenesis 21: in diabetic rat lenses taurine supplementation partially reduces damage resulting from osmotic compensation leading to osmolyte loss and antioxidant depletion. Exp Eye Res 69:279–289PubMedCrossRefGoogle Scholar
  43. Nakamura Y, Fukiage C, Azuma M, Shearer TR (1999) Oxidation enhances calpain-induced turbidity in young rat lenses. Curr Eye Res 19:33–40PubMedCrossRefGoogle Scholar
  44. Olofsson EM, Marklund SL, Behndig A (2007) Glucose-induced cataract in CuZn-SOD null lenses: an effect of nitric oxide? Free Radic Biol Med 42:1098–1105PubMedCrossRefGoogle Scholar
  45. Ostadalova I, Babicky A, Obenberger J (1978) Cataract induced by administration of a single dose of sodium selenite to suckling rats. Experientia 34:222–223PubMedCrossRefGoogle Scholar
  46. Ozaki Y, Mizuno A, Itoh K, Iriyama K (1987) Inter- and intra-molecular disulfide bond formation and related structural changes in the lens proteins. A Raman spectroscopic study in vivo of lens aging. J Biol Chem 262:15545–15551PubMedGoogle Scholar
  47. Padival S, Nagaraj RH (2006) Pyridoxamine inhibits Maillard reactions in diabetic rat lenses. Ophthalmic Res 38:294–302PubMedCrossRefGoogle Scholar
  48. Rayman MP (2005) Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc 64:527–542PubMedCrossRefGoogle Scholar
  49. Satake M, Dmochowska B, Nishikawa Y, Madaj J, Xue J, Guo Z, Reddy DV, Rinaldi PL, Monnier VM (2003) Vitamin C metabolomic mapping in the lens with 6-deoxy-6-fluoro-ascorbic acid and high-resolution 19 F-NMR spectroscopy. Invest Ophthalmol Vis Sci 44:2047–2058PubMedCrossRefGoogle Scholar
  50. Saxena P, Saxena AK, Monnier VM (1996) High galactose levels in vitro and in vivo impair ascorbate regeneration and increase ascorbate-mediated glycation in cultured rat lens. Exp Eye Res 63:535–545PubMedCrossRefGoogle Scholar
  51. Shamsi FA, Sharkey E, Creighton D, Nagaraj RH (2000) Maillard reactions in lens proteins: methylglyoxal-mediated modifications in the rat lens. Exp Eye Res 70:369–380PubMedCrossRefGoogle Scholar
  52. Shearer TR, Anderson RS, Britton JL (1983) Influence of selenite and fourteen trace elements on cataractogenesis in the rat. Invest Ophthalmol Vis Sci 24:417–423PubMedGoogle Scholar
  53. Shearer TR, David LL, Anderson RS, Azuma M (1992) Review of selenite cataract. Curr Eye Res 11:357–369PubMedCrossRefGoogle Scholar
  54. Shearer TR, Ma H, Fukiage C, Azuma M (1997) Selenite nuclear cataract: review of the model. Mol Vis 3:8–15PubMedGoogle Scholar
  55. Son HY, Kim H, Kwon YH (2007) Taurine prevents oxidative damage of high glucose-induced cataractogenesis in isolated rat lenses. J Nutr Sci Vitaminol 53:324–330PubMedCrossRefGoogle Scholar
  56. Spector A, Kuszak JR, Ma W, Wang RR, Ho Y, Yang Y (1998) The effect of photochemical stress upon the lenses of normal and glutathione peroxidase-1 knockout mice. Exp Eye Res 67:457–471PubMedCrossRefGoogle Scholar
  57. Stadtman TC (1991) Biosynthesis and function of selenocysteine-containing enzymes. J Biol Chem 266:16257–16260PubMedGoogle Scholar
  58. Swamy-Mruthinti S, Green K, Abraham EC (1996) Inhibition of cataracts in moderately diabetic rats by aminoguanidine. Exp Eye Res 62:505–510PubMedCrossRefGoogle Scholar
  59. Ueda Y, Fukiage C, Shih M, Shearer TR, David LL (2002) Mass measurements of C-terminally truncated α-crystallins from two-dimensional gels identify Lp82 as a major endopeptidase in rat lens. Mol Cell Proteomics 1:357–365PubMedCrossRefGoogle Scholar
  60. Worgul BV, Medvedovsky C, Huang Y, Marino SA, Randers-Pehrson G, Brenner DJ (1996) Quantitative assessment of the cataractogenic potential of very low doses of neutrons. Radiat Res 145:343–349PubMedCrossRefGoogle Scholar
  61. Xu GT, Zigler JS Jr, Lou MF (1992) Establishment of a naphthalene cataract model in vitro. Exp Eye Res 54:73–81PubMedCrossRefGoogle Scholar
  62. Zigler JS Jr, Qin C, Kamiya T, Krishna MC, Cheng Q, Tumminia S, Russell P (2003) Tempol-H inhibits opacification of lenses in organ culture. Free Radic Biol Med 35:1194–1202PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.SD Pharma Solutions Inc.VictoriaCanada

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