Respiratory Function Assays in Safety Pharmacology

Reference work entry

Abstract

The objectives of a safety pharmacology study of the respiratory system are to determine whether a drug has the potential to produce a change in respiratory function and to establish whether this change is a liability. Such changes can result from either the primary or secondary pharmacological properties of a drug or from organ dysfunction resulting from the toxicological properties of a drug.

Keywords

Inspiratory Flow Ventilatory Parameter Pleural Pressure Differential Pressure Transducer Sodium Cyanide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgments

I would like to thank Jonathan Renninger for his many technical and scientific contributions and Robert Coatney for his surgical contributions to the development of the respiratory models used in our laboratory.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Safety PharmacologyGlaxoSmithKline PharmaceuticalsKing of PrussiaUSA

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