Bioanalytical Assays LC-MS/MS

Reference work entry

Abstract

Powerful analytical techniques are one key requirement for successful drug research and development. The concentration of drugs, prodrugs, and metabolites has to be determined in very diverse matrices such as plasma (blood), urine, feces, and also in different organ tissues (depending on the nature of the drug and on the targeted organs).

Keywords

Solid Phase Extraction Matrix Effect Quality Control Sample Acceptance Criterion Atmospheric Pressure Chemical Ionization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References and Further Reading

  1. Abu-Qare AW, Abou-Donia MB (2001) J Pharm Biomed Anal 26:939–947PubMedCrossRefGoogle Scholar
  2. Annesley TM (2003) Clin Chem 49:1041–1044PubMedCrossRefGoogle Scholar
  3. Baker SD, Zhao M, He P, Carducci MA, Verweij J, Sparreboom A (2004) Anal Biochem 324:276–284PubMedCrossRefGoogle Scholar
  4. Barratè S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q (2004) J Chromatogr A 1024:87–94CrossRefGoogle Scholar
  5. Beck O, Stephanson N, Morris RG, Sallustio BC, Hjemdahl P (2004) J Chromatogr B 805:87–91CrossRefGoogle Scholar
  6. Bogialli S, Curini R, Di Corcia A, Nazzari M, Sergi M (2003) Rapid Commun Mass Spectrom 17:1146–1156PubMedCrossRefGoogle Scholar
  7. Bonato PS, Del Lama MPFM, de Carvalho R (2003) J Chromatogr B 796:413–420CrossRefGoogle Scholar
  8. Boner PL, Liu DDW, Feely WF, Robinson RA, Wu J (2003) J Agric Food Chem 51:7555–7559PubMedCrossRefGoogle Scholar
  9. Chambers E, Wagrowski-Diehl DM, Lu Z, Mazzeo JR (2007) J Chromatogr B 852:22–34CrossRefGoogle Scholar
  10. Chu F, Kiang CH, Sung ML, Huang B, Reeve RL, Tarnowski T (1999) J Pharm Biomed Anal 21:657–667PubMedCrossRefGoogle Scholar
  11. Cole RB (ed) (1997) Electrospray ionisation mass spectrometry-fundamentals, instrumentation and applications. Wiley, New YorkGoogle Scholar
  12. CPMP/ICH/281/95 (1996) EEC note for guidance, validation of analytical procedures: methodology, LondonGoogle Scholar
  13. CPMP/ICH/381/95 (1994) EEC note for guidance on validation of analytical procedures: definitions and terminology, LondonGoogle Scholar
  14. Crommentuin KML, Rosing H, Hillebrand MJX, Huitema ADR, Beijnen JH (2004) J Chromatogr 804:359–367CrossRefGoogle Scholar
  15. Dams R, Huestis MA, Lambert WE, Murphy CM (2003) J Am Soc Mass Spectrom 14:1290–1294PubMedCrossRefGoogle Scholar
  16. De Jonge ME, van Dam SM, Hillebrand MJX, Rosing H, Huitema ADR, Rodenhuis S, Beijnen JH (2004) J Mass Spectrom 39:262–271PubMedCrossRefGoogle Scholar
  17. Ding J, Neue UD (1999) Rapid Commun Mass Spectrom 13:2151–2159PubMedCrossRefGoogle Scholar
  18. Dole M, Match LL, Hines RL, Mobley RC, Ferguson LD, Alice MB (1968) J Chem Phys 49:2240–2249CrossRefGoogle Scholar
  19. Dorschel CA, Ekmanis JL, Oberholtzer JE, Warren FV, Bidlingmeyer BA (1989) LC detectors: evaluation and practical implications of linearity. Anal Chem 61:951–968CrossRefGoogle Scholar
  20. EMA/CHMP/EWP/192217/2009 Guideline on bioanalytical method validation, valid 1 Feb 2012Google Scholar
  21. Gaskell SJ (1997) J Mass Spectrom 32:677–688CrossRefGoogle Scholar
  22. Getie M, Neubert RHH (2004) J Pharm Biomed Anal 35:921–927PubMedCrossRefGoogle Scholar
  23. Guevremont R (2004) High-field asymmetric waveform ion mobility spectrometry: a new tool for mass spectrometry. J Chromatogr A 1058:3–19PubMedGoogle Scholar
  24. Hopfgartner G, Bourgogne E (2003) Mass Spectrom Rev 22:195–214PubMedCrossRefGoogle Scholar
  25. Hou W, Watters JW, McLeod HL (2004) J Chromatogr B 804:263–267CrossRefGoogle Scholar
  26. Hows MEP, Ashmeade TE, Billinton A, Perren MJ, Austin AA, Virley DJ, Organ AJ, Shah AJ (2004) J Neurosci Methods 137:221–226PubMedCrossRefGoogle Scholar
  27. Hüsgen AG (2006) Fast and ultra-fast analysis with the agilent 1200 series rapid resolution LC system compared to a conventional agilent 1100 series LC system using sub 2-μm particle columns. Application Note, publication number 5989-5672ENGoogle Scholar
  28. Ito Y, Goto T, Oka H, Matsumoto H, Takeba K (2004) J Chromatogr A 1042:107–111PubMedCrossRefGoogle Scholar
  29. Jamal M, Ouyang Z, Powell ML (2000) J Pharm Biomed Anal 23:323–340CrossRefGoogle Scholar
  30. Jennings W (1987) Analytical gas chromatography. Academic, LondonGoogle Scholar
  31. Jin SE, Ban E, Kim YB, Kim CK (2004) J Pharm Biomed Anal 35:929–936PubMedCrossRefGoogle Scholar
  32. Kasel D, Jetter A, Harlafinger S, Gebhardt W, Fuhr U (2004) Rapid Commun Mass Spectrom 18:1472–1478PubMedCrossRefGoogle Scholar
  33. Keller JH, Karas M, Müller WE, Volmer DA, Eckert GP, Tawab MA, Blume HH, Dingermann T, Schubert-Zsilavecz M (2003) Anal Chem 75:6084–6088PubMedCrossRefGoogle Scholar
  34. King R, Bonfiglio R, Fernandez-Metzler C, Miller-Stein C, Olah T (2000) J Am Soc Mass Spectrom 11:942–950PubMedCrossRefGoogle Scholar
  35. Kollroser M, Schober C (2002) J Pharm Biomed Anal 28:1173–1182PubMedCrossRefGoogle Scholar
  36. Laurito TL, Mendes GD, Vincenzo S, Caliendo G, de Moraes MEA, De Nucci G (2004) J Mass Spectrom 39:168–176PubMedCrossRefGoogle Scholar
  37. Liang HR, Foltz RL, Meng M, Bennett P (2003) Rapid Commun Mass Spectrom 17:2815–2821PubMedCrossRefGoogle Scholar
  38. Lim CK, Lord G (2002) Biol Pharm Bull 26:547–557CrossRefGoogle Scholar
  39. Moeller MR, Steinmeyer S, Kraemer T (1998) J Chromatogr B 713:91–109CrossRefGoogle Scholar
  40. O’Connor D (2002) Curr Opin Drug Discov Devel 5:52–58PubMedGoogle Scholar
  41. Pascoe R, Foley JP, Gusev AI (2001) Anal Chem 73:6014–6023PubMedCrossRefGoogle Scholar
  42. Pichini S, Pacifici R, Pellegrini M, Marchei E, Lozano J, Murillo J, Vall O, Garcia-Algar O (2004) Anal Chem 76:2124–2132PubMedCrossRefGoogle Scholar
  43. Raffaelli A, Saba A (2003) Mass Spectrom Rev 22:318–331PubMedCrossRefGoogle Scholar
  44. Robb DB, Covey TR, Bruins AP (2000) Anal Chem 72:3653–3659PubMedCrossRefGoogle Scholar
  45. Schuhmacher J, Zimmer D, Tesche F, Pickard V (2003) Rapid Commun Mass Spectrom 17:1950–1957PubMedCrossRefGoogle Scholar
  46. Shah VP (2007) AAPS J 9:E43–E47CrossRefGoogle Scholar
  47. Shah VP, Midha KK, Findlay JW, Hill HM, Hulse JD, McGilveray IJ, McKay G, Miller KJ, Patnaik RN, Powell ML, Tonelli A, Viswanathan CT, Yacobi A (2000) Pharm Res 17:1551–1557PubMedCrossRefGoogle Scholar
  48. Sottani C, Zuchetti M, Zaffaroni M, Bettinelli M, Minoia C (2004) Rapid Commun Mass Spectrom 18:1017–1023PubMedCrossRefGoogle Scholar
  49. Stovkis E, Nan-Offeringa GAH, Ouwehand M, Tibben MM, Rosing H, Schnaars Y, Grigat M, Romeis P, Schellens JHM, Beijnen JH (2004a) Rapid Commun Mass Spectrom 18:1465–1471CrossRefGoogle Scholar
  50. Stovkis E, Rosing H, López-Lázaro L, Beijnen JH (2004b) J Mass Spectrom 39:431–436CrossRefGoogle Scholar
  51. Swartz ME (2005) Sep Sci Redefin 5:8–14Google Scholar
  52. Tiller PR, Romanyshyn LA, Neue UD (2003) Anal Bioanal Chem 337:788–802CrossRefGoogle Scholar
  53. U.S. Department of Health and Human Services Food and Drug Administration (2001) Guidance for industry: bioanalytical method validation. U.S: Department of Health and Human Services, BeltsvilleGoogle Scholar
  54. Venn RF (ed) (2000) Principles of bioanalysis. Taylor & Francis, LondonGoogle Scholar
  55. Viberg A, Sandström M, Jansson B (2004) Rapid Commun Mass Spectrom 18:707–710PubMedCrossRefGoogle Scholar
  56. Viswanathan CT, Bansal S, Booth B, DeStefano AJ, Rose MJ, Sailstad J, Shah VP, Skelli JP, Swann PG, Weiner R (2007) AAPS J 9:E30–E42CrossRefGoogle Scholar
  57. Whitehouse CM, Dreyer RN, Yamashita M, Fenn JB (1985) Anal Chem 57:675–679PubMedCrossRefGoogle Scholar
  58. Willoughby R, Sheehan E, Mitrovich S (1998) A global view of LC/MS. Global View Publishing, PittsburghGoogle Scholar
  59. Xia YQ, Whigan DB, Jemal M (1999) Rapid Commun Mass Spectrom 13:1611–1621PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Sanofi Deutschland GmbHFrankfurt am MainGermany
  2. 2.Sanofi Deutschland GmbH, R&D DSAR / Drug Disposition FF, Industriepark HöchstFrankfurt am MainGermany

Personalised recommendations