Spatial Clustering and Autocorrelation in Health Events
Spatial autocorrelation in health events may be the signature of underlying causal factors of direct scientific and practical interest but may also be due to pedestrian or nuisance factors that obscure meaningful spatial patterns. The problem is to discern spatial patterns that inform our understanding of the health events themselves from those that are of little interest. This chapter provides a framework for advancing knowledge when the causes of observed health event clusters are unknown.
KeywordsSpatial Autocorrelation West Nile Virus Lyme Disease Behavioral Risk Factor Surveillance System Neutral Model
The author’s efforts were funded in part by grants 2R44CA112743, 5R44CA135818, and 1R21LM011132 from the National Cancer Institute and the National Library of Medicine. The perspectives are those of the author and do not necessarily represent those of the funding agencies.
- Aldstad J (2010) Spatial clustering. In: Fischer MM, Getis A (eds) Handbook of applied spatial analysis. Software tools, methods and applications. Springer, Berlin/Heidelberg/New York, pp 270–300Google Scholar
- Cuzick J, Edwards R (1990) Spatial clustering for inhomogeneous populations. J R Stat Soc B 52(1):73–104Google Scholar
- Ecker DJ, Massire C, Blyn LB, Hofstadler SA, Hannis JC, Eshoo MW, Hall TA, Sampath R (2009) Molecular genotyping of microbes by multilocus PCR and mass spectrometry: a new tool for hospital infection control and public health surveillance. In: Molecular epidemiology of microorganisms. Springer, Berlin/Heidelberg/New York, pp 71–87CrossRefGoogle Scholar
- Goovaerts P (2009) Medical geography: a promising field of application for geostatistics. Math Geol 41(3):243–264Google Scholar
- Johnson G, Buckeridge D, Dearth S, Ditty J, Finelli L, Hopkins RS, Hummel J, et al. (2012) Draft guidelines for syndromic surveillance using inpatient and ambulatory clinical care EHR data. A report from the international society for disease surveillance: international society for disease surveillanceGoogle Scholar
- Neutra RR (1990) Counterpoint from a cluster buster. Am J Epidemiol 132(1):1–8Google Scholar
- Rimoin AW, Mulembakani PM, Johnston SC, Lloyd JO, Smith NK, Kisalu TL, Kinkela SB et al (2010) Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci 107(37):16262–16267. doi:10.1073/pnas.1005769107CrossRefGoogle Scholar
- Sattenspiel L, Lloyd A (2010) The geographic spread of infectious diseases: models and applications. Princeton University Press, PrincetonGoogle Scholar
- Turnbull BW, Iwano EJ, Burnett WS, Howe HL, Clark LC (1990) Monitoring for clusters of disease: application to leukemia incidence in upstate New York. Am J Epidemiol 132(1 Suppl):S136–S143Google Scholar