Natural Products pp 4001-4015 | Cite as

Eugenol as Local Anesthetic

  • Gehoon Chung
  • Seog Bae Oh
Reference work entry


Eugenol is an active ingredient of essential oil extracted from cloves and other herbs. Eugenol is used extensively in dentistry for its analgesic and anti-inflammatory activities. However, the molecular mechanism underlying the pharmacological action of eugenol is only recently investigated. This chapter discusses eugenol’s abilities to modulate various ion channels that are responsible for nociception, generation of neuronal spikes, and synaptic transmission. Therapeutic use of eugenol as antibiotic, anti-inflammatory, antitumor, and antioxidant agent is described and then followed by other aspects of eugenol such as cytotoxicity, insecticidal activity, allergic reaction, and olfactory response. In conclusion, eugenol is a versatile natural compound that has many potential uses in wide areas.


Eugenol analgesic anesthetic anti-inflammatory antibiotic 



This research was supported by grant (2011-0018614) from National Research Laboratory Program grant (2011-0027592) from Midcareer Researcher program and grant (2011 K000275) from Brain Research Center of the twenty-first Century Frontier Research Program funded by the Ministry of Education, Science and Technology, Republic of Korea. There is no conflict of interest.


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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.National Research Laboratory for Pain, Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National UniversitySeoulKorea

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