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Natural Products pp 3345-3366 | Cite as

Quassinoids: Chemistry and Novel Detection Techniques

  • Dipjyoti ChakrabortyEmail author
  • Amita Pal
Reference work entry

Abstract

Natural products play a dominant role in pharmaceutical industry, providing resources for the discovery of new drug molecules. Quassinoids are degraded triterpenes reported from the members of the Simarouboidaea subfamily of Simaroubaceae. The importance of quassinoids as antiplasmodial, anticancer and anti-HIV compounds has revived interest in them as potential drug candidates. Its efficacy as combinatorial drug coupled with the structure–activity analysis has reclaimed novel structural leads for new drug development. Quassinoids are categorized into five distinct groups according to their basic skeleton, viz., C-18, C-19, C-20, C-22, and C-25. This present entry reviews the structure, structure–activity relationship, and methods of isolation, detection, and characterization of quassinoids. Recent LC–MS/MS-based techniques could effectively provide more lead molecules which would act in synergism with other compounds.

Keywords

Mass spectrometry quantitative structure–activity relationship Quassinoid 

Abbreviations

ESI

Electrospray ionization

GABA

Gamma-aminobutyric acid

GC

Gas chromatography

HIV

Human immunodeficiency virus

HPLC

High-performance liquid chromatography

LC

Liquid chromatography

MALDI

Matrix-assisted laser desorption/ionization

MS

Mass spectrometry

NMR

Nuclear magnetic resonance

QESAR

Quantitative electronic structure–activity relationship

QSAR

Quantitative structure–activity relationship

SAR

Structure–activity relationship

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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Bioscience and BiotechnologyBanasthali VidyapithBanasthaliIndia
  2. 2.Division of Plant BiologyBose InstituteKolkataIndia

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