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Natural Products pp 2665-2691 | Cite as

Terpenes: Chemistry, Biological Role, and Therapeutic Applications

  • Priyanka P. Brahmkshatriya
  • Pathik S. BrahmkshatriyaEmail author
Reference work entry

Abstract

Terpenoids are naturally occurring hydrocarbons produced by a wide variety of plants and animals. They are classified based on five-carbon (isoprene) units as their building blocks, numbering more than 55,000 molecules having been discovered till date. Different terpenes include hemiterpenes (C5), monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), sesterterpenes (C25), triterpenes (C30), and polyterpenes (>C30). Diverse functional roles of terpenoids have been critically studied and well-accepted now. Some of them include natural flavor additives for food or fragrances in perfumery and in traditional and alternate medicines as aromatherapy. Biosynthetically, terpenoids are formed via two major synthetic pathways: mevalonic acid (MVA) pathway and 2C-methyl-D-erythritol-4-phosphate (MEP) pathway. Biologically active terpenoids span various orders of magnitude. Most comprehensively studied of which is the effect of terpenes in prevention and treatment of cancer. Illustratively, Taxol derivative (paclitaxel and docetaxel) are among the widely used drugs in cancer chemotherapy. Other important therapeutic uses of terpenoids include antimicrobial, antifungal, antiviral, antihyperglycemic, anti-inflammatory, antioxidants, antiparasitic, immunomodulatory, and as skin permeation enhancer. Since many of these molecules are only found in very low levels in nature, their massive harvesting to obtain sufficient amounts of the drug including synthetic biology and metabolic engineering provides innovative approaches to increase the production of terpenoids.

Keywords

Antibacterial anticancer antiparasitic anti-inflammatory antiviral biosynthesis isoprene unit 

Abbreviations

COX

Cyclooxygenase

DMAPP

Dimethylallyl pyrophosphate

DXP

1-Deoxy-D-xylulose-5-phosphate

FPP

Farnesyl pyrophosphate

GGPP

Geranylgeranyl pyrophosphate

GPP

Geranyl pyrophosphate

HIV

Human immunodeficiency virus

HSV

Herpes simplex virus

IL

Interleukin

iNOS

Inducible nitric oxide synthetase

IPP

Isopentenyl pyrophosphate

MEP

2C-Methyl-D-erythritol-4-phosphate

MIC

Minimum inhibitory concentration

MVA

Mevalonic acid

NF

Nuclear factor

PG

Prostaglandin

PL

Phospholipase

TNF

Tumor necrosis factor

WBC

White blood cells

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Priyanka P. Brahmkshatriya
    • 1
  • Pathik S. Brahmkshatriya
    • 2
    Email author
  1. 1.Department of PharmacologyL. J. Institute of PharmacyAhmedabadIndia
  2. 2.Institute of Organic Chemistry and Biochemistry, v.v.i. and Gilead Sciences and IOCB Research CenterAcademy of Sciences of the Czech RepublicPragueCzech Republic

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