Encyclopedia of Biophysics

2013 Edition
| Editors: Gordon C. K. Roberts

Segmented Flow Microfluidics

  • Ioannis G. Lignos
  • Robert C. R. Wootton
  • Andrew J. DeMello
  • Bradley M. Stone
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16712-6_721


During the past two decades, the use of miniaturized systems for the manipulation and processing of fluid samples has gained significant interest because of their chemical, biological, and biomedical applications. This interest in large part has been driven by concomitant advances in the areas of genomics, proteomics, drug discovery, high-throughput screening, and diagnostics, with a clearly defined need to perform rapid measurements on small sample volumes. At a basic level, microfluidic activities have been motivated by the fact that physical processes can be more easily controlled when instrumental dimensions are reduced to the micron scale. Key additional benefits include the ability to process small volumes of fluid, enhance analytical performance, reduce instrumental footprints, lower unit costs, and facilitate integration of functional components within monolithic substrates and the capacity to exploit atypical fluid behavior in both time and space.

In broad terms,...

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Copyright information

© European Biophysical Societies' Association (EBSA) 2013

Authors and Affiliations

  • Ioannis G. Lignos
    • 1
  • Robert C. R. Wootton
    • 1
  • Andrew J. DeMello
    • 1
  • Bradley M. Stone
    • 2
  1. 1.Department of Chemistry and Applied BiosciencesInstitute for Chemical and Bioengineering, ETH ZurichZurichSwitzerland
  2. 2.Department of ChemistrySan Jose State UniversitySan JoseUSA