Encyclopedia of Biophysics

2013 Edition
| Editors: Gordon C. K. Roberts

Electron Transfer in Catalases and Catalase-Peroxidases

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16712-6_51
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Definition

Catalases (EC 1.11.1.6) are enzymes that catalyze the disproportionation of hydrogen peroxide into water and molecular oxygen by means of a heme iron or a dinuclear manganese active site. They have an essential role in the regulation of the cellular concentration of hydrogen peroxide.

Catalase-peroxidases, also named KatGs in relation to the encoding katG gene, are heme-containing oxidoreductases that are capable of disproportionation of hydrogen peroxide as monofunctional catalases, as well as of oxidation of substrates via high-valence iron-oxo intermediates as monofunctional peroxidases. KatGs can also perform INH lyase, NADH oxidase, and isonicotinoyl-NADH synthase reactions.

Basic Characteristics

Catalases are protective enzymes that convert the potentially damaging H 2O 2 into H 2O and O 2. Catalases fall into three distinct phylogenetic groups: the heme-containing monofunctional catalases, the heme-containing catalase-peroxidases and the manganese-containing catalases....
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References

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© European Biophysical Societies' Association (EBSA) 2013

Authors and Affiliations

  1. 1.CNRS (UMR 8221) and CEA-SaclayiBiTec-S, Laboratory of Hyperfrequencies, Metalloproteines and Systems of SpinGif-sur-YvetteFrance
  2. 2.Department of MicrobiologyUniversity of ManitobaWinnipegCanada