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Ion Channels: New Tools to Track Cyclic Nucleotide Changes in Living Cells

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Encyclopedia of Biophysics

Synonyms

Cyclic nucleotides; Spatiotemporal organization of cyclic nucleotides; Ion channels as biosensors

Definition

Ion channels are used as biosensors in order to visualize the spatiotemporal changes that occur in cyclic nucleotides in living cells.

Introduction

Ion channels are pore-forming proteins that allow the flow of ions down their electrochemical gradient thus helping to establish and control the small voltage gradient across the plasma membrane of cells. They are present in the membranes that surround all biological cells and can be distinguished based upon their ion selectivity, gating mechanism, and sequence similarity. Ion channels can be voltage gated, ligand gated, pH gated, or mechanically gated. These gating criteria along with a combination of sequence similarity and ion selectivity further subdivide ion channels into several subtypes:

  • Voltage-gated ion channels which open and close in response to membrane potential such as the voltage-gated sodium channels,...

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Authors and Affiliations

  1. INSERM UMR–S–769, LabEx LERMIT, University of Paris-South, 5, Rue Jean-Baptiste Clément, Châtenay–Malabry, F-92296, France

    Aniella Abi-Gerges & Rodolphe Fischmeister

Authors
  1. Aniella Abi-Gerges
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  2. Rodolphe Fischmeister
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Corresponding author

Correspondence to Rodolphe Fischmeister .

Editor information

Editors and Affiliations

  1. Department of Biochemistry, University of Leicester, Leicester, UK

    Gordon C. K. Roberts

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Abi-Gerges, A., Fischmeister, R. (2013). Ion Channels: New Tools to Track Cyclic Nucleotide Changes in Living Cells. In: Roberts, G.C.K. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16712-6_377

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