Encyclopedia of Biophysics

2013 Edition
| Editors: Gordon C. K. Roberts

Dynamic Clamp: Synthetic Conductances and Their Influence on Membrane Potential

  • Hugh P. C. RobinsonEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16712-6_368

Synonyms

Definition

Dynamic clamp refers to the use of a computer to stimulate neurons or other excitable cells with a signal (usually an electrical current) which is calculated in real-time using feedback of the membrane potential. Most often, this is done to inject conductance which mimics the electrical behavior of membrane ion channels, for example, synaptic or voltage-gated channels.

Introduction

The earliest use of an artificial membrane conductance as an experimental tool for studying excitable cells is probably the simulation of a gap-junctional connection between cardiac muscle cells by an analog resistor, described by Tan & Joyner in 1990, an idea which also appears in the Ph.D. thesis by Scott in 1979 (see Goaillard and Marder 2006). Dynamic clamp, in its usual sense of using a freely programmable digital computer, in a feedback loop comprising analog-to-digital conversion, a...

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References

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Copyright information

© European Biophysical Societies' Association (EBSA) 2013

Authors and Affiliations

  1. 1.Department of Physiology, Development and NeuroscienceUniversity of CambridgeCambridgeUK