Encyclopedia of Biophysics

2013 Edition
| Editors: Gordon C. K. Roberts

Surface-Enhanced Raman Spectroscopy for Bioanalytics

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16712-6_119
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Synonyms

 DNA;  SERRS;  SERS

Definitions

Surface enhanced Raman spectroscopy for bioanalytics is the exploitation of the spectroscopic technique, SERS, for bioanalytical applications. Two examples of bioanalytical target classes which have benefited from SERS detection strategies are nucleic acid and enzymatic detection.

DNA Detection by Surface-Enhanced Raman Scattering (SERS)

The sensitive and selective detection of DNA is of fundamental importance to the improvement of analytical and therapeutic methods for human health. Surface-enhanced (resonance) Raman scattering (SE(R)RS) spectroscopy has been applied to the sensitive and selective detection of DNA (Hering et al. 2008; Schlucker 2009). Arguably the greatest advantage that SERS spectroscopy offers as an analytical tool is that the spectra provide distinct vibrational information about the molecule being interrogated, making the technique highly suitable for the instantaneous detection of several analytes, that is, multiplexed...
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Copyright information

© European Biophysical Societies' Association (EBSA) 2013

Authors and Affiliations

  • Duncan Graham
    • 1
  • Karen Faulds
    • 1
  • Jennifer A Dougan
    • 1
  1. 1.Centre for Molecular Nanometrology WestCHEM, Department of Pure and Applied ChemistryUniversity of StrathclydeGlasgowUK