Definition
Decoy receptors recognize certain growth factors (such as Vascular Endothelial Growth Factor) or cytokines with high affinity and specificity, but are structurally incapable of signaling or presenting the agonist to signaling receptor complexes. They act as a molecular trap for the agonist and for signaling receptor components. A decoy receptor, or sink receptor, is a receptor that binds a ligand, inhibiting it from binding to its normal receptor. For instance, the receptor VEGFR-1 can prevent vascular endothelial growth factor (VEGF) from binding to the VEGFR-2.
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© 2011 Springer-Verlag Berlin Heidelberg
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(2011). Decoy Receptor. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_6693
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DOI: https://doi.org/10.1007/978-3-642-16483-5_6693
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16482-8
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