Accelerated senescence, the process of rapid terminal growth arrest, is accompanied by phenotypic features of cell senescence (enlarged and flattened morphology, increased granularity, expression of specific biochemical, and enzymatic markers such as senescence-associated β-galactosidase activity). It can be induced in normal cells by DNA damage or introduction of mutant RAS and is also induced in tumor cells by different anticancer drugs or ionizing radiation.

 Mitotic Catastrophe

 Senescence and Immortalization