Definition
Pharmacokinetics
Pharmacokinetics (PK) is the study of how a drug is absorbed, distributed, metabolized, and excreted over time.
Pharmacodynamics
Pharmacodynamics (PD) is the study of how a drug affects its target(s) in a dose- and time-dependent fashion.
Characteristics
To maximize the chance of successful drug development, a comprehensive knowledge of the compound under investigation is required. Assuming the drug target has been correctly selected, drug efficacy requires delivery into the patient such that adequate drug concentration is achieved within the plasma and tumor (measured by PK studies) to effect target modulation (measured by PD studies), resulting in anticancer effect(s). These principles have been incorporated into a pharmacological audit trail consisting of a series of questions that should be addressed during drug design and development. These can be summarized as:
Is the drug target expressed in the tumor of interest?
Are adequate plasma and tumor drug...
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© 2011 Springer-Verlag Berlin Heidelberg
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Pacey, S., Workman, P., Sarker, D. (2011). Pharmacokinetics and Pharmacodynamics in Drug Development. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_4501
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DOI: https://doi.org/10.1007/978-3-642-16483-5_4501
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16482-8
Online ISBN: 978-3-642-16483-5
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