Skip to main content

p21

  • 510 Accesses

Synonyms

CAP20; CDKN1A; Cip1; Cyclin-dependent kinase inhibitor 1A; mda-6; Sdi1; Waf1

Definition

Traditionally, the p21 protein has been defined as an inhibitor of cyclin-dependent kinases (CDKs). Inhibition of this group of enzymes by p21 leads to the cessation of cell proliferation. Additionally, p21 binds to and inhibits the activity of PCNA (proliferating cell nuclear antigen, a subunit of DNA polymerase), which results in the termination of DNA replication. Because both of these functions lead to cell cycle arrest, p21 is also called an inhibitor of the cell cycle.

Additional functions of p21 were discovered that are unrelated to its ability to inhibit cell proliferation. For example, p21 can regulate transcription, restrain apoptosis, impose on cytoskeletal dynamics and cell motility, interfere with cellular differentiation, senescence and aging, act as cytoplasmic regulator of nuclear import, impinge on DNA repair, and affect the generation of induced pluripotent stem cells...

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-16483-5_4327
  • Chapter length: 7 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   2,499.99
Price excludes VAT (USA)
  • ISBN: 978-3-642-16483-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
p21. Fig. 1
p21. Fig. 2
p21. Fig. 3

References

  1. Sherr CJ, Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501–1512

    CAS  PubMed  CrossRef  Google Scholar 

  2. Child ES, Mann DJ (2006) The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability. Cell Cycle 5:1313–1319

    CAS  PubMed  CrossRef  Google Scholar 

  3. Besson A, Dowdy SF, Roberts JM (2008) CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14:159–169

    CAS  PubMed  CrossRef  Google Scholar 

  4. Abbas T, Dutta A (2009) p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 9:400–414

    CAS  PubMed  PubMed Central  CrossRef  Google Scholar 

  5. Jung YS, Qian Y, Chen X (2010) Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 22:1003–1012

    CAS  PubMed  PubMed Central  CrossRef  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Axel H. Schönthal .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Schönthal, A.H. (2011). p21. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_4327

Download citation