Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

Micelles

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_3707

Definition

Are the simplest form of amphiphilic assembly, being an aggregate of surfactant molecules dispersed in a liquid colloid. In aqueous solution, typical micelles form an aggregate with the hydrophilic “head” regions on the outside and the hydrophobic tail regions sequestered in the center. Block copolymers with amphipathic characteristics can be assembled to form micelles that incorporate anticancer drugs or DNA. Such micelles are small enough (50–100 nm in diameter) to reach tumors by crossing the walls of tumor vessels.

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© Springer-Verlag Berlin Heidelberg 2011