Synonyms
Definition
Metastasis is the growth of a tumor at a site not physically connected to the primary tumor.
Characteristics
The presence of metastasis is a key feature in determining the prognosis and the treatment strategy for any cancer patient. The probability that a patient will have a metastasis varies widely depending upon the type of cancer. Squamous cell carcinoma of the skin rarely metastasizes, but squamous cell carcinoma of the lung frequently does. An important part of the clinical workup for every patient who is diagnosed with cancer is an evaluation for metastasis. The presence and extent of metastases are a critical component of clinical Staging systems that clinicians use to choose appropriate therapy and to judge prognosis.
Metastases follow different routes that can be broadly classified into three. One is metastasis to the regional lymph nodes or lymphatic metastasis. This involves colonization of draining lymph nodes. The second is...
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Gupta GP, Minn AJ, Kang Y et al (2005) Identifying site-specific metastasis genes and functions. Cold Spring Harb Symp Quant Biol 70:149–158
Kopfstein L, Christofori G (2006) Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment. Cell Mol Life Sci 63:449–468
Sohara Y, Shimada H, DeClerck YA (2005) Mechanisms of bone invasion and metastasis in human neuroblastoma. Cancer Lett 228:203–209
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Muschel, R.J. (2011). Metastasis. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_3671
Download citation
DOI: https://doi.org/10.1007/978-3-642-16483-5_3671
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16482-8
Online ISBN: 978-3-642-16483-5
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences