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Lysophosphatidylcholine (LPC) is a major plasma lipid constituent that is produced from phosphatidylcholine (PC).
LPC is produced from PC under a variety of physiological and pathological conditions. LPC is present at high levels (about 100 μM) in plasma under normal conditions and exists mainly in albumin- or lipoprotein-bound forms. The biochemical conversion from PC to LPC is mediated by phospholipase A1 or phospholipase A2. Sequentially, LPC is converted to lysophosphatidate (LPA) by lysophospholipase D (autotaxin) (Fig. 1).
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