Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab


  • Geum-Youn GwakEmail author
  • Jung-Hwan Yoon
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_3471



Lysophosphatidylcholine (LPC) is a major plasma lipid constituent that is produced from phosphatidylcholine (PC).


LPC is produced from PC under a variety of physiological and pathological conditions. LPC is present at high levels (about 100 μM) in plasma under normal conditions and exists mainly in albumin- or lipoprotein-bound forms. The biochemical conversion from PC to LPC is mediated by  phospholipase A1 or  phospholipase A2. Sequentially, LPC is converted to  lysophosphatidate (LPA) by lysophospholipase D (autotaxin) (Fig.  1).
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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSouth Korea
  2. 2.Department of Internal MedicineSeoul National University College of MedicineChongno-guSouth Korea