Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

Lysophosphatidylcholine

  • Geum-Youn Gwak
  • Jung-Hwan Yoon
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_3471

Synonyms

Definition

Lysophosphatidylcholine (LPC) is a major plasma lipid constituent that is produced from phosphatidylcholine (PC).

Characteristics

LPC is produced from PC under a variety of physiological and pathological conditions. LPC is present at high levels (about 100 μM) in plasma under normal conditions and exists mainly in albumin- or lipoprotein-bound forms. The biochemical conversion from PC to LPC is mediated by  phospholipase A1 or  phospholipase A2. Sequentially, LPC is converted to  lysophosphatidate (LPA) by lysophospholipase D (autotaxin) (Fig.  1).
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References

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    Xu Y (2002) Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. Biochim Biophys Acta 1582:81–88PubMedCrossRefGoogle Scholar
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    Brindley DN (2004) Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer. J Cell Biochem 92:900–912PubMedCrossRefGoogle Scholar
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    Tomura H, Mogi C, Sato K et al (2005) Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors. Cell Signal 17:1466–1476PubMedCrossRefGoogle Scholar
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    Gwak GY, Yoon JH, Lee SH et al (2006) Lysophosphatidylcholine suppresses apoptotic cell death by inducing cyclooxygenase-2 expression via a Raf-1 dependent mechanism in human cholangiocytes. J Cancer Res Clin Oncol 132:771–779PubMedCrossRefGoogle Scholar
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    Meyer zu Heringdorf D, Jakobs KH (2007) Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism. Biochim Biophys Acta 1768:923–940PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSouth Korea
  2. 2.Department of Internal MedicineSeoul National University College of MedicineChongno-guSouth Korea