Definition
IQGAP1 is the best-characterized member of the IQGAP family of eukaryotic proteins that were first identified in 1994 in metastatic human osteosarcoma cells. This family of proteins is found in a wide spectrum of species and is highly conserved throughout the evolution from yeast to human. The name refers to the presence of “IQ” motifs and a domain similar to Ras GTPase-activating proteins (GAP).
Characteristics
IQGAP1 is a member of IQGAP family that has been characterized in yeast, Hydra, worms, and mammals. The human IQGAP1 isoform is most similar to mouse IQGAP1 (94% identity) and has 62% identity to human IQGAP2. IQGAP1 is the prototype of this family and the most extensively studied member. IQGAP1 is a multimodular scaffolding protein that binds to a diverse array of signaling and structural molecules which confers it many different roles in cell physiology. IQGAP1 domains and target proteins are presented in Fig. 1...
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References
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Balenci, L., Baudier, J. (2011). IQGAP1 Protein. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_3144
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DOI: https://doi.org/10.1007/978-3-642-16483-5_3144
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