Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

Anaphase-Promoting Complex

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_253


The anaphase is a phase of mitosis, during which the paired sister-chromatids ( Sister-chromatids) are separated and drawn to the poles of the cell. This phase is initiated by a ubiquitin-mediated proteolytic pathway ( Ubiquitination) resulting in the degradation of regulatory proteins. The anaphase-promoting complex (APC/C) functions as a protein ubiquitin ligase.


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© Springer-Verlag Berlin Heidelberg 2011