Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

Fever of Unknown Origin

  • Henrik Toft Sørensen
Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_2162

Synonyms

Definition

Fever of unknown origin is a clinical syndrome of  fever that does not resolve spontaneously within 3 weeks and the cause remains unknown after extensive workup. Fever is defined as an elevation of the body temperature that exceeds the normal daily variation. The hypothalamus controls the body temperature and a normal body temperature is ordinarily maintained because the hypothalamic thermal regulatory center balances the excess heat production derived from metabolic activities in the muscles and the liver with heat dissipation from the skin and lungs. Normally, healthy adult individuals have a mean oral temperature of 36.8°C ± 0.4°C. The temperature is a little bit higher in the evening. Fever of unknown origin is an important clinical challenge. In 1961, Petersdorf and Beeson [1] defined it in their first report as an illness characterized by fever of more...

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References

  1. 1.
    Petersdorf RG, Beeson PB (1961) Fever of unexplained origin: report on 100 cases. Medicine (Baltimore) 40:1–30CrossRefGoogle Scholar
  2. 2.
    Mourad O, Palda V, Detsky AS (2003) A comprehensive evidence-based approach to fever of unknown origin. Arch Intern Med 163:545–551PubMedCrossRefGoogle Scholar
  3. 3.
    Vanderschueren S, Knockaert D, Adriaenssens T et al (2003) From prolonged febrile illness to fever of unknown origin: the challenge continues. Arch Intern Med 163:1033–1041PubMedCrossRefGoogle Scholar
  4. 4.
    Arnow PM, Flaherty JP (1997) Fever of unknown origin. Lancet 350:575–580PubMedCrossRefGoogle Scholar
  5. 5.
    Sørensen HT, Mellemkjær L, Skriver MV et al (2005) Fever of unknown origin and cancer: a population-based study. Lancet Oncol 6:851–855PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Henrik Toft Sørensen
    • 1
  1. 1.Department of Clinical EpidemiologyAarhus University HospitalAarhus CDenmark