Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

Complement-Dependent Cytotoxicity

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_1286


CDC refers to the lysis of a target cell in the presence of  complement system proteins. The complement activation pathway is initiated by the binding and fixation of the first component of the complement system (CIq) to the fragment crystalline (Fc) region of a (therapeutic) antibody complexed with a cognate antigen. The end result is a membrane attack complex that generates a hole in the cell membrane, ultimately causing cell lysis and death.




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© Springer-Verlag Berlin Heidelberg 2011