Encyclopedia of Cancer

2011 Edition
| Editors: Manfred Schwab

Clathrin

Reference work entry
DOI: https://doi.org/10.1007/978-3-642-16483-5_1207

Definition

The major structural component of coated pits constituted by a larger, ∼190 KDa protein, the clathrin heavy chain, which is complex to a smaller (∼25 KDa) subunit, the clathrin light chain. Heavy–light chain dimers can further assemble into complexes called triskelions, which represent the building blocks of the polygonal array that constitutes the organizing scaffold of a pit.

 Endocytosis

 Huntingtin Interacting Protein 1 (HIP1)

Copyright information

© Springer-Verlag Berlin Heidelberg 2011