Autocatalysis, cross-catalysis, informational molecule
Self-replication occurs when an informational molecule (such as a nucleic acid) directs the spontaneous synthesis of a replica of itself. Mechanisms for self-replication can be autocatalytic, where a molecule acts as a template to make a direct copy of itself, or cross-catalytic, where two or more molecules of different informational content amplify one another. Modern life forms use a complex cross-catalytic mechanism of replication that involves the participation of protein molecules that catalyze the replication of the informational polymer (nucleic acids), which are also involved in the synthesis of the catalysts themselves. Primordial life, however, could...
References and Further Reading
- Schrum JP, Ricardo A, Krishnamurty M, Blain JC, Szostak JW (2009) Efficient and rapid tempate-directed nucleic acid copying using 2′-amino-2′-3′-dideoxyribonucleoside-5′-phosphorimidazolide monomers. J Am Chem Soc 131:14560Google Scholar
- Terfort A, von Kiedrowski G (1992) Self-replication by condensation of 3-aminobenzamidines and 2-formylphenoxyacetic acids. Angew Chem Int Ed 31:654Google Scholar
- Tjivikua T, Ballester P, Rebek J (1990) A self-replicating system. 112:1249Google Scholar
- von Kiedrowski G (1986) A sel-replicating hexadeoxynucleotide. Angew Chem Int Ed 25:932Google Scholar