Nutritional Modulation of Intestinal Gene Expression

Reference work entry

Childhood is a time of great change in nutrient intake. This review will examine how nutritional changes alter the expression of genes in the intestine (the point of interaction between the child and the nutritional environment). Unlike other organs, the intestine is not shielded from the major environmental changes of childhood. In the fetus, the intestinal lumen is sterile and the fetal circulation provides nourishment. But after birth, it interacts with an extremely complex environment containing nutrients in varying concentrations. At weaning, this level of complexity increases further.

Altering the expression of genes has become a rapidly developing area of research in medicine. The realization that gene expression is important in a wide range of diseases (and not just in inherited disease) has resulted in the whole field of gene expression being recognized as one which may bring new therapeutic options. Although most recent attention has focused on the benefits of altering gene...

Keywords

Long Terminal Repeat Histone Acetylation Intestinal Epithelium Intestinal Lumen Sodium Butyrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Centre for Digestive Diseases, Blizard InstituteBarts and The London School of Medicine and Dentistry, Queen Mary, University of LondonLondonUK

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