Anterior Horn Cell Diseases
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Disorders of the anterior horn cell (AHC) can either be acquired or inherited. Acquired diseases are mainly of viral origin and most of these run an acute course. They include poliomyelitis and similar diseases due to enteroviruses other than poliovirus. Following the global control of poliomyelitis by widespread immunization, inherited degenerative diseases currently account for most cases of AHC disease.
The polioviruses belong to the Piccornaviridae family, in the genus Entrovirus and include three antigenically distinct serotypes (types 1, 2, and 3). They spread by the fecal–oral route and humans are the only known reservoir. Polioviruses are known to be resistant and can retain infectivity for several days at room temperature.
Paralytic poliomyelitis occurs in about 1/1,000 infections among infants to about 1/100 infections among adolescents. Prior to universal vaccination, epidemics of paralytic poliomyelitis occurred...
KeywordsWest Nile Virus Spinal Muscular Atrophy Survival Motor Neuron Anterior Horn Cell SMN1 Gene
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