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Human Herpes Viruses Type 6 and 7

  • David W. KimberlinEmail author
Reference work entry

Introduction

In 1986, a novel virus was isolated from six patients with lymphoproliferative syndromes, two of whom were also infected with the human immunodeficiency virus (HIV). Molecular and structural characterization of the new virus revealed an icosahedral core structure of 162 capsomeres, indicating that it was a herpesvirus. However, serological comparisons failed to demonstrate immunologic cross-reactivity with the five human herpesviruses known to exist at the time. Subsequent genomic analysis confirmed that the newly isolated virus was distinct from herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV). Due to the initial belief that the new virus selectively infected freshly isolated human B cells, the virus was given the name human B-lymphotropic virus (HBLV). Subsequent investigation revealed a broader cell tropism, with notable T-cell lymphotropism. For this reason, current...

Keywords

Primary Infection Febrile Seizure Human Herpesvirus Congenital Infection Infected Respiratory Tract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Asano Y, Yoshikawa T, Suga S, Kobayashi I, Nakashima T, Yazaki T, Kajita Y, Ozaki T (1994) Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). Pediatrics 93:104–109PubMedGoogle Scholar
  2. Caserta MT, Hall CB (1993) Human herpesvirus-6. Annu Rev Med 44:377–383PubMedCrossRefGoogle Scholar
  3. Caserta MT, Hall CB, Schnabel K, McIntyre K, Long C, Costanzo M, Dewhurst S, Insel R, Epstein LG (1994) Neuroinvasion and persistence of human herpesvirus 6 in children. J Infect Dis 170:1586–1589PubMedCrossRefGoogle Scholar
  4. Caserta MT, Hall CB, Schnabel K, Long CE, D’Heron N (1998) Primary human herpesvirus 7 infection: a comparison of human herpesvirus 7 and human herpesvirus 6 infections in children. J Pediatr 133:386–389PubMedCrossRefGoogle Scholar
  5. Caserta MT, McDermott MP, Dewhurst S, Schnabel K, Carnahan JA, Gilbert L, Lathan G, Lofthus GK, Hall CB (2004) Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children. J Pediatr 145:478–484PubMedCrossRefGoogle Scholar
  6. Caserta MT, Hall CB, Schnabel K, Lofthus G, McDermott MP (2007) Human herpesvirus (HHV)-6 and HHV-7 infections in pregnant women. J Infect Dis 196:1296–1303PubMedGoogle Scholar
  7. Caserta MT, Hall CB, Schnabel K, Lofthus G, Marino A, Shelley L, Yoo C, Carnahan J, Anderson L, Wang H (2010) Diagnostic assays for active infection with human herpesvirus 6 (HHV-6). J Clin Virol 48:55–57PubMedCrossRefGoogle Scholar
  8. Cone RW, Huang ML, Ashley R, Corey L (1993) Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals. J Clin Microbiol 31:1262–1267PubMedGoogle Scholar
  9. Dewhurst S, Chandran B, McIntyre K, Schnabel K, Hall CB (1992) Phenotypic and genetic polymorphisms among human herpesvirus-6 isolates from North American infants. Virology 190:490–493PubMedCrossRefGoogle Scholar
  10. Dewhurst S, McIntyre K, Schnabel K, Hall CB (1993) Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants. J Clin Microbiol 31:416–418PubMedGoogle Scholar
  11. Frenkel N, Schirmer EC, Wyatt LS, Katsafanas G, Roffman E, Danovich RM, June CH (1990) Isolation of a new herpesvirus from human CD4+ T cells. Proc Natl Acad Sci USA 87:748–752PubMedCrossRefGoogle Scholar
  12. Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, Knott A, Dewhurst S, Insel RA, Epstein LG (1994) Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med 331:432–438PubMedCrossRefGoogle Scholar
  13. Hall CB, Caserta MT, Schnabel KC, Long C, Epstein LG, Insel RA, Dewhurst S (1998) Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A. Clin Infect Dis 26:132–137PubMedCrossRefGoogle Scholar
  14. Hall CB, Caserta MT, Schnabel KC, Boettrich C, McDermott MP, Lofthus GK, Carnahan JA, Dewhurst S (2004) Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). J Pediatr 145:472–477PubMedCrossRefGoogle Scholar
  15. Hall CB, Caserta MT, Schnabel KC, McDermott MP, Lofthus GK, Carnahan JA, Gilbert LM, Dewhurst S (2006) Characteristics and acquisition of human herpesvirus (HHV) 7 infections in relation to infection with HHV-6. J Infect Dis 193:1063–1069PubMedCrossRefGoogle Scholar
  16. Hall CB, Caserta MT, Schnabel K, Shelley LM, Marino AS, Carnahan JA, Yoo C, Lofthus GK, McDermott MP (2008) Chromosomal integration of human herpesvirus 6 is the major mode of congenital human herpesvirus 6 infection. Pediatrics 122:513–520PubMedCrossRefGoogle Scholar
  17. Hall CB, Caserta MT, Schnabel KC, Shelley LM, Carnahan JA, Marino AS, Yoo C, Lofthus GK (2010) Transplacental congenital human herpesvirus 6 infection caused by maternal chromosomally integrated virus. J Infect Dis 201:505–507PubMedCrossRefGoogle Scholar
  18. Leach CT, Sumaya CV, Brown NA (1992) Human herpesvirus-6: clinical implications of a recently discovered, ubiquitous agent. J Pediatr 121:173–181PubMedCrossRefGoogle Scholar
  19. Levy JA, Ferro F, Greenspan D, Lennette ET (1990) Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population. Lancet 335:1047–1050PubMedCrossRefGoogle Scholar
  20. Pruksananonda P, Hall CB, Insel RA, McIntyre K, Pellett PE, Long CE, Schnabel KC, Pincus PH, Stamey FR, Dambaugh TR et al (1992) Primary human herpesvirus 6 infection in young children. N Engl J Med 326:1445–1450PubMedCrossRefGoogle Scholar
  21. Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B et al (1986) Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234:596–601PubMedCrossRefGoogle Scholar
  22. Secchiero P, Carrigan DR, Asano Y, Benedetti L, Crowley RW, Komaroff AL, Gallo RC, Lusso P (1995) Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis 171:273–280PubMedCrossRefGoogle Scholar
  23. Segondy M, Astruc J, Atoui N, Echenne B, Robert C, Agut H (1992) Herpesvirus 6 infection in young children. N Engl J Med 327:1099–1100PubMedCrossRefGoogle Scholar
  24. Steeper TA, Horwitz CA, Ablashi DV, Salahuddin SZ, Saxinger C, Saltzman R, Schwartz B (1990) The spectrum of clinical and laboratory findings resulting from human herpesvirus-6 (HHV-6) in patients with mononucleosis-like illnesses not resulting from Epstein-Barr virus or cytomegalovirus. Am J Clin Pathol 93:776–783PubMedGoogle Scholar
  25. Takahashi K, Sonoda S, Kawakami K, Miyata K, Oki T, Nagata T, Okuno T, Kamanishi K (1988) Human herpesvirus 6 and exanthem subitum. Lancet 1:1463PubMedCrossRefGoogle Scholar
  26. Tanaka K, Kondo T, Torigoe S, Okada S, Mukai T, Yamanishi K (1994) Human herpesvirus 7: another causal agent for roseola (exanthem subitum). J Pediatr 125:1–5PubMedCrossRefGoogle Scholar
  27. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T (1988) Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1:1065–1067PubMedCrossRefGoogle Scholar
  28. Yamanishi K, Kondo K, Mukai T, Kondo T, Nagafuji H, Kato T, Okuno T, Kurata T (1992) Human herpesvirus 6 (HHV-6) infection in the central nervous system. Acta Paediatr Jpn 34:337–343PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Division of Pediatric Infectious DiseasesThe University of Alabama at BirminghamBirminghamUSA

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