Human Herpes Viruses Type 6 and 7

  • David W. KimberlinEmail author
Reference work entry


In 1986, a novel virus was isolated from six patients with lymphoproliferative syndromes, two of whom were also infected with the human immunodeficiency virus (HIV). Molecular and structural characterization of the new virus revealed an icosahedral core structure of 162 capsomeres, indicating that it was a herpesvirus. However, serological comparisons failed to demonstrate immunologic cross-reactivity with the five human herpesviruses known to exist at the time. Subsequent genomic analysis confirmed that the newly isolated virus was distinct from herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV). Due to the initial belief that the new virus selectively infected freshly isolated human B cells, the virus was given the name human B-lymphotropic virus (HBLV). Subsequent investigation revealed a broader cell tropism, with notable T-cell lymphotropism. For this reason, current...


Primary Infection Febrile Seizure Human Herpesvirus Congenital Infection Infected Respiratory Tract 
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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Division of Pediatric Infectious DiseasesThe University of Alabama at BirminghamBirminghamUSA

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