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Aging of Skin Cells in Culture

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Book cover Textbook of Aging Skin

Abstract

The study of age-related changes in the physiology, biochemistry, and molecular biology of isolated skin cell populations in culture has greatly expanded the understanding of the fundamental aspects of skin aging. In modern biogerontology, the terms “cellular aging,” “cell senescence,” or “replicative senescence” most commonly imply the study of normal diploid cells in culture, which during serial subcultivation undergo a multitude of changes culminating in the permanent cessation of cell division. This process of cellular aging in vitro is generally known as the Hayflick phenomenon, and the limited division potential of normal cells is called the Hayflick limit, in recognition of the observations first reported by Leonard Hayflick in 1961 [1]. With respect to skin aging, three main cell types have been studied extensively with respect to cellular aging in vitro: dermal fibroblasts, epidermal keratinocytes, and melanocytes [2–7].

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Author information

Authors and Affiliations

  1. Laboratory of Cellular Ageing, Department of Molecular Biology, Aarhus University, DK8000 Aarhus – C, Denmark

    Suresh I. S. Rattan

Authors
  1. Suresh I. S. Rattan
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Editors and Affiliations

  1. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Miranda A. Farage Ph.D. (Principal Scientist) (Principal Scientist)

  2. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Kenneth W. Miller Ph.D. (Associate Director) (Associate Director)

  3. Department of Dermatology, University of California, School of Medicine, 222 SE 8th Ave., Suite 563, 94122, San Francisco, CA, USA

    Howard I. Maibach M.D. (Professor) (Professor)

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© 2010 Springer-Verlag Berlin Heidelberg

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Rattan, S.I.S. (2010). Aging of Skin Cells in Culture. In: Farage, M.A., Miller, K.W., Maibach, H.I. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89656-2_50

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  • DOI: https://doi.org/10.1007/978-3-540-89656-2_50

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89655-5

  • Online ISBN: 978-3-540-89656-2

  • eBook Packages: MedicineReference Module Medicine

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