Fibulin-5 Deposition in Human Skin: Decrease with Aging and UVB Exposure and Increase in Solar Elastosis

  • Satoshi Amano
Reference work entry

Abstract

Skin aging is classified into two types, intrinsic aging and photoaging. Intrinsic aging is a basic biological process common to all living things, and can be characterized as age-dependent deterioration of skin functions and structures, such as epidermal atrophy and epidermal–dermal junction flattening [1]. Histologically, intrinsically aged skin has an atrophied extracellular matrix with a reduced amount of elastin [2]. On the other hand, photoaging is well known to be a consequence of chronic exposure to sunlight. Sun-exposed skin, such as the skin on the face or neck, is apparently prematurely aged compared with the relatively sun-protected skin of the trunk, and is characterized by various clinical features, including wrinkles, sagging, roughness, sallowness, pigmentary changes, telangiectasia, and neoplasia [3, 4], and histological features of sun-exposed skin including cellular atypia, loss of polarity, epidermal–dermal junction flattening, a decrease in collagen, and dermal elastosis, with abnormal deposition of elastotic material in the dermis [1, 5]. Damage to skin collagen and elastin (extracellular matrix) is the hallmark of long-term exposure to solar ultraviolet irradiation, and is believed to be responsible for the wrinkled appearance of sun-exposed skin [5].

Keywords

Elastic Fiber Skin Aging Papillary Dermis Reticular Dermis Cutis Laxa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Satoshi Amano
    • 1
  1. 1.Shiseido Research CenterTsuzuki-kuJapan

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