Skip to main content

Topical Growth Factors for Skin Rejuvenation

  • Reference work entry

Abstract

Growth factors are polypeptides or proteins, which play a key role in the regulation of a number of physiological processes operating at extremely low concentrations [1]. Together with cytokines, they are important regulators of cell division, differentiation, chemotaxis and adhesion, cellular trafficking, cell activation, apoptosis, cell survival, and transformation. They typically mediate interactions between cells within a specific tissue microenvironment, thereby, binding its corresponding receptor located on the outer surface of the target cell, which ultimately results in a biological response in a complex cascade of events.

Keywords

  • Glycyrrhetinic Acid
  • Fetal Fibroblast
  • Fetal Skin
  • Multiple Growth Factor
  • Skin Rejuvenation

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-540-89656-2_100
  • Chapter length: 9 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   499.00
Price excludes VAT (USA)
  • ISBN: 978-3-540-89656-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Figure 100.1

References

  1. Taub DD. Cytokine, growth factor, and chemokine ligand database. Curr Protoc Immunol. 2004;6.29.1–6.29.89.

    Google Scholar 

  2. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83:835–870.

    CAS  PubMed  Google Scholar 

  3. Braund R, Hook S, Medlicott N. The role of topical growth factors in chronic wounds. Curr Drug Deliv. 2007;4:195–204.

    CAS  CrossRef  PubMed  Google Scholar 

  4. Barrientos S, Stojadinovic O, Golinko MS, et al. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16:585–601.

    CrossRef  PubMed  Google Scholar 

  5. Leahy PJ, Lawrence WT. Biologic enhancement of wound healing. Clin Plast Surg. 2007;34:659–671.

    CrossRef  PubMed  Google Scholar 

  6. Bullard KM, Longaker MT, Lorenz HP. Fetal wound healing: current biology. World J Surg. 2003;27:54–61.

    CrossRef  PubMed  Google Scholar 

  7. Fitzpatrick RE, Rostan EF. Reversal of photodamage with topical growth factors: a pilot study. J Cosmet Laser Ther. 2003;5:25–34.

    CrossRef  PubMed  Google Scholar 

  8. Fitzpatrick RE. Endogenous growth factors as cosmeceuticals. Dermatol Surg. 2005;31:827–831.

    CAS  CrossRef  PubMed  Google Scholar 

  9. Beanes SR, Dang C, Soo C, et al. Skin repair and scar formation: the central role of TGF-β. Expert Rev Mol Med. 2003;21:1–22.

    Google Scholar 

  10. Gosain A, DiPietro LA. Aging and wound healing. World J Surg. 2004;28:321–326.

    CrossRef  PubMed  Google Scholar 

  11. Swift ME, Kleinman HK, DiPietro LA. Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest. 1999;79:1479–1487.

    CAS  PubMed  Google Scholar 

  12. Komi-Kuramochi A, Kawano M, Oda Y, et al. Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice. J Endocrinol. 2005;186:273–289.

    CAS  CrossRef  PubMed  Google Scholar 

  13. Lorenz HP, Lin RY, Longaker MT, et al. The fetal fibroblast: The effector cell of scarless fetal skin repair. Plast Reconstr Surg. 1995;96:1251–1259.

    CAS  CrossRef  PubMed  Google Scholar 

  14. Ferguson MW, O’Kane S. Scar-free healing: From embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B. 2004;359:839–850.

    CAS  CrossRef  Google Scholar 

  15. Wu L, Siddiqui A, Morris DE, et al. Transforming growth factor beta 3 (TGF beta 3) accelerates wound healing without alteration of scar prominence. Histologic and competitive reverse-transcription-polymerase chain reaction studies. Arch Surg. 1997;132:753–760.

    CAS  PubMed  Google Scholar 

  16. Uitto J. The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure. J Drugs Dermatol. 2008;7(Suppl 2):s12–s16.

    PubMed  Google Scholar 

  17. Baumann L. Skin ageing and its treatment. J Pathol. 2007;211:241–251.

    CAS  CrossRef  PubMed  Google Scholar 

  18. Seite S, Zucchi H, Septier D, et al. Elastin changes during chronological and photo-ageing: the important role of lysozyme. J Eur Acad Dermatol Venereol. 2006;20:980–987.

    CAS  PubMed  Google Scholar 

  19. Yaar M, Gilchrest BA. Photoageing: mechanism, prevention and therapy. Br J Dermatol. 2007;157:874–887.

    CAS  CrossRef  PubMed  Google Scholar 

  20. Rao J, Ehrlich M, Goldman MP. Facial skin rejuvenation with a novel topical compound containing transforming growth factor β1 and vitamin C. Cosmet Dermatol. 2004;17:705–713.

    Google Scholar 

  21. Ehrlich M, Rao J, Pabby A, et al. Improvement in the appearance of wrinkles with topical transforming growth factor β1 and L-ascorbic acid. Dermatol Surg. 2006;32:618–625.

    CAS  CrossRef  PubMed  Google Scholar 

  22. Mehta RC, Smith SR, Grove GL, et al. Reduction in facial phtodamage by a tropical growth factor product. J Drugs Dermatol. 2008;7:864–871.

    PubMed  Google Scholar 

  23. Kupper TS, Groves RW. The interleukin-1 axis and cutaneous inflammation. J Invest Dermatol. 1995;105(Suppl 1):62S–66S.

    CAS  CrossRef  PubMed  Google Scholar 

  24. Gold MH, Goldman MP, Biron J. Efficacy of novel skin cream containing mixture of human growth factors and cytokines for skin rejuvenation. J Drugs Dermatol. 2007;6:197–201

    PubMed  Google Scholar 

  25. Gold MH, Goldman MP, Biron J. Human growth factor and cytokine skin cream for facial skin rejuvenation as assessed by 3D in vivo optical skin imaging. J Drugs Dermatol. 2007;6:1018–1023.

    PubMed  Google Scholar 

  26. Lévêque JL. EEMCO guidance for the assessment of skin topography. J Eur Acad Dermatol Venereol. 1999;12:103–114.

    PubMed  Google Scholar 

  27. Friedman PM, Skover GR, Payonk G, et al. 3D in-vivo optical skin imaging for topographical quantitative assessment of non-ablative laser technology. Dermatol Surg. 2002;28:199–204.

    CrossRef  PubMed  Google Scholar 

  28. Hussain M, Phelps R, Goldberg DJ. Clinical, histologic, and ultrastructural changes after use of human growth factor and cytokine skin cream for the treatment of skin rejuvenation. J Cosmet Laser Ther. 2008;10:104–109.

    CrossRef  PubMed  Google Scholar 

  29. Lupo ML, Cohen JL, Rendon MI. Novel eye cream containing a mixture of human growth factors and cytokines for periorbital skin rejuvenation. J Drugs Dermatol. 2007;6:725–729.

    PubMed  Google Scholar 

  30. Gilchrest BA. Treatment of photodamage with topical tretinoin: an overview. J Am Acad Dermatol. 1997;36:S27–S36.

    CAS  CrossRef  PubMed  Google Scholar 

  31. Hayes BB, Afshari A, Millecchia L, et al. Evaluation of percutaneous penetration of natural rubber latex proteins. Toxicol Sci. 2000;56:262–270.

    CAS  CrossRef  PubMed  Google Scholar 

  32. Glogau RG. Topically applied botulinum toxin type A for the treatment of primary axillary hyperhidrosis: results of a randomized, blinded, vehicle-controlled study. Dermatol Surg. 2007;33:S76–S80.

    CAS  CrossRef  PubMed  Google Scholar 

  33. Schaefer H, Lademann J. The role of follicular penetration. A differential view. Skin Pharmacol Appl Skin Physiol. 2001;14(Suppl 1):23–27.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Rangarajan, V., Dreher, F. (2010). Topical Growth Factors for Skin Rejuvenation. In: Farage, M.A., Miller, K.W., Maibach, H.I. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89656-2_100

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-89656-2_100

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89655-5

  • Online ISBN: 978-3-540-89656-2

  • eBook Packages: MedicineReference Module Medicine