Reference Work Entry

Textbook of Aging Skin

pp 1079-1087

Topical Growth Factors for Skin Rejuvenation

  • Vijayeta RangarajanAffiliated withNEOCUTIS Inc.
  • , Frank DreherAffiliated withNEOCUTIS Inc.


Growth factors are polypeptides or proteins, which play a key role in the regulation of a number of physiological processes operating at extremely low concentrations [1]. Together with cytokines, they are important regulators of cell division, differentiation, chemotaxis and adhesion, cellular trafficking, cell activation, apoptosis, cell survival, and transformation. They typically mediate interactions between cells within a specific tissue microenvironment, thereby, binding its corresponding receptor located on the outer surface of the target cell, which ultimately results in a biological response in a complex cascade of events.